HSD-016 |CAS 946396-92-5|DC Chemicals

Cas No.:	946396-92-5
Chemical Name:	HSD-016
Synonyms:	C4I13768E1;(2R)-1,1,1-trifluoro-2-[3-[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonylphenyl]propan-2-ol;DB12419;Q27275182;(R)-1,1,1-Trifluoro-2-(3-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)phenyl)propan-2-ol;Unii-C4I13768E1;HSD-016
SMILES:	O[C@](C(F)(F)F)(C)C1=CC=CC(S(=O)(N2[C@H](C)CN(C3=CC=C(F)C=C3C(F)(F)F)CC2)=O)=C1
Formula:	C₂₁H₂₁F₇N₂O₃S
M.Wt:	514.456868886948
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively; significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes with IC50 of 362 nM; HSD-016 (HSD016) has entered phase I clinical trials for the treatment of diabetes.

COA

MSDS

Cat. No.	Product name	Field of application
DC8278	BVT-14225	BVT 14225 is a new selective 11b-HSD1 inhibitor, it belongs to a class of arylsulfonamidothiazoles with in vitro and in vivo antidiabetic effects
DC11206	HSD-016	HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.