Human B-type natriuretic peptide, facilitating cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldosterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation

Novel non-peptidic, non-covalent cruzain inhibitor

The first potent NAD-driven small molecular inhibitor of TcGAPDH (Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase)

Novel AR inhibitor, being selective for the testosterone stimulated AR-dependent prostate cancer cell

Natural inducer of autophagy and apoptosis, inhibiting glutamate overexcitation and upregulation of the Wnt/β-catenin signaling pathway

Potent natural anti-tumor agent against metastatic colorectal cancer, resulting in cell cycle arrest at the G2/M phase and inducing apoptosis through the dysfunction of mitochondria to trigger intrinsic apoptotic pathway by untargeted metabolomic method,

Inhibitor of the formation of

Natural inhibitor of tumor metastasis by upregulating the RNA-binding-protein MBNL2, inducing cell cycle arrest through multiple signaling pathways including RNA binding protein CELF6

Novel ATP-competitive inhibitor of Nek2 and Nek7

Novel Inhibitor of DNA Glycosylases, inhibiting NEIL1 activity

Non-narcotic analgesic for the relief of acute and chronic pain

Novel inhibitor of caspase-independent cell death with necrotic morphol, distinctly different from apoptosis, autophagy, and necroptosis, displaying strong mitochondrial reactive oxygen species and ONOO- scavenging activity

Novel necroptosis inhibitor

Negative control compound for Necrostatin-1 related assays

Novel Inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1)

Novel G4-DNA ligand, promoting transcription in Gram-positive bacteria and repressing transcription in Gram-negatives

Major metabolite of loperamide, also used as the precusor for radiolabelled loperamide

Precursor for radiolabeled diltiazem

Inhibitor of Phosphodiesterase (PDE)-2

Potent and selective inhibitor for gelatinases, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MPP9)

Selective water-soluble gelatinase inhibitor

Novel potent and highly specific IRAK4 inhibitor

Novel degrader of steroid receptor co-activator 1 (SRC-1)

Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects

Cyanogen Bromide adduct of (R)-SCH-12679, a D1 antagonist

Novel HMG-CoA reductase inhibitor and nitric oxide donor

Novel NO-donor, suppressing inflammatory and nociceptive responses

Novel blocker of the interaction between FGF1 and FGFRD2 to inhibit cell proliferation, showing potent antiproliferent with less cytotoxicity.

Beclin 1 mimetic, selectively binding to Bcl-xL and inducing autophagy, showing potent cytotoxicity in PC-3, PC-3a and DU145 prostate cancer cells

Analogue of γ-hydroxybutyric acid (GHB), acting as a substrate for both the monocarboxylate transporter subtype 1 (MCT1) and subtype 4 (MCT4)