Novel endothelin receptor antagonist, suppressing the upregulation of matrix metalloproteinases and connexin 43 in hyperthyroid myocardium

Novel inhibitor of death-associated protein kinase 1 (DAPK1), also inhibiting VEGF-receptor 2 and tyrosine-protein kinase SRC

Novel positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGlu5)

Novel selective NADPH oxidase 2 (Nox2) inhibitor, attenuating endothelial cell inflammation and vessel dysfunction and restoring mouse hind-limb flow

Novel selective NADPH oxidase 2 (Nox2) inhibitor, attenuating endothelial cell inflammation and vessel dysfunction and restoring mouse hind-limb flow

Novel CpIMPDH inhibitor

Unique inhibitor of MDM2, inhibiting MDM2-p53 interaction and promoting MDM2 degradation

Novel selective inhibitor of the CREB binding protein (CBP)

Novel potent inhibitor of CpFIKK catalytic activity

Novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein

Novel inhibitor of against human liver FBPase (IC50, 0.029±0.006 μM) and high selectivity relative to the other six AMP-binding enzymes, producing significant glucose-lowering effects on both type 2 diabetic KKAy mice and ZDF rats

Novel nonnucleoside reverse transcriptase inhibitor (NNRTI)

Potent PPARα agonist with a Ki of 10.8 nM

Novel Mdr1 P-glycoprotein substrate

Novel selective α5 GABA A receptor agonist

Inhibitor of Kv1.3 potassium ion channels

Inhibitor of glycogen phosphorylase; Antidiabetic

Novel potent and selective p38alpha inhibitor

Potent and selective leukotriene B4 antagonist

Novel viral propagation inhibitor, binding to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE), stabilizing the hairpin's folded state and reducing frameshifting efficiency in cells

Novel Potent Mitochondria-Targeted Photodynamic Therapy Anticancer Agent

Novel Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

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Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclode​xtrin

Selective glucocorticoid receptor antagonist

Novel class I mutation corrector, rescuing CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis

Novel photoCORM, exhibiting good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach in cancerous B16F10 cells

Natural potent cytotoxic agent against multiple cancer cell lines, acting on cells as a protein synthesis inhibitor, targeting the eukaryotic translation elongation factor 1A (eEF1A), a target shared by other lipophilic cyclic peptide natural products

Novel positive allosteric modulator of the GABA(B) receptor

Novel positive allosteric modulator of the GABA(B) receptor