Novel potent and selective melanocortin-4 receptor inhibitor, possessing 15-fold selectivity for the MC4R versus the MC3R

Novel fluorescent copper probe

A mixture of estrogen hormones used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women, being also used to replace estrogen in women with ovarian failure or other conditions tha

Natural triketide pyrone, functioning as a sulfate shuttle and its sulfated derivative being accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediate

Novel inducer of Klotho (KL) expression

Dual inhibitor of phospholipid transfer protein and microsomal triglyceride transfer protein

Inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines

Inhibitor of tubulin polymerization; vascular disrupting agent (VDA)

Inhibitor of tubulin polymerization, preventing cancer cells from producing microtubules

Natural differentiation inducer of human promyelocytic leukemia cells

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Natural lariat depsipeptide, inhibiting VEGFA/VEGFR2 expression and suppressing tumor growth in glioblastoma xenografts, targeting Sec61 to prevent biogenesis of secretory and membrane proteins

Novel inhibitor of mitogen-activated protein kinase (MAPK)

Novel potent RIPK1/necroptosis ligand, penetrate the blood-brain barrier

Novel and selective noncompetitive antagonist of the NMDA

N-methyl-D-aspartate (NMDA) receptor ligand, selectivity targeting the intrachannel PCP/ketamine/MK-801 site of NMDA receptor

Novel potent and selective blocker of the calcineurin-NFAT interaction (KD=16nM), preventing acute lung injury, being a promising novel treatment for ARDS and other inflammatory diseases

Novel partial blocker of GluK1, with GluK2 being unaffected

Novel blocker of binding of CXCL12 to CXCR4

Novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor

Novel Potent Inhibitor of the HIV-1 Nucleocapsid Protein

Novel Inhibitor for RNA-Dependent RNA Polymerase of Norovirus

Novel TRPV1 modulator, also modulating both CB1 and CB2 receptors

Selective and potent potentiator of nAChRs containing an α4

Novel allosteric modulator of the β2 adrenergic receptor (β2AR), binding to a pocket formed primarily by the cytoplasmic ends of transmembrane segments 1, 2, 6 and 7 as well as intracellular loop 1 and helix 8

Inhibitor of DprE1, an epimerase required for cell wall biosynthesis

Potent dual 5-lipoxygenase (5-LOX) inhibitor and platelet-activating factor (PAF) receptor antagonist

Novel SARS-CoV Mpro inhibitor which has its P1-phenylalanine residue bound to the relatively hydrophilic S1 pocket of the enzyme and yet exhibits a high inhibitory activity against SARS-CoV Mpro, with Ki = 2.24 ± 0.58 μM