Ganoderic Acid is reported to exhibit anti-tumor activity mediated through its inhibitory effect on NFKB and AP-1 as well as antimetastasis and anti-HIV activities.

Specific PSAC antagonist that blocks channels from only the Dd2 parasite line

A fluorescent substrate for the synaptic vesicle monoamine transporters

Novel modulator of Nr2e3, slowing the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations.

Potent activator of SHIP-1 inducing apoptosis of the cancer cell lines in vitro in both a time and dose dependant manner

Novel selective inhibitors of FAS-TE; Inhibitor of the thioesterase domain of fatty acid synthase

Natural potent male antifertility agent

Novel potent and selective PRMT5 inhibitor, demonstrating tumor regression in a biomarker-driven human small cell lung cancer

Novel inhibitor of heat shock protein Hsp90, inducing p53-mediated apoptosis in MCF-7 cells

Selective MMP-1 inhibitor

Novel inhibitor of the vesicular monoamine transporter 2 (VMAT2)

Novel NR2D-preferring antagonist  inhibiting NMDA-EPSCs

Annonacin is a potent and lipophilic acetogenin from A. muricata that inhibits mitochondrial complex I (IC50 = 54.8 nM).1,2 Annonacin induces ATP depletion, tau pathologies, and dopaminergic cell death in rats (EC50s = 134, 44.1, and 60.8 nM, respectively

The first selective antagonist of orphan receptor GPR18

Novel inhibitor of BAF transcriptional repression

The novel fluorescent probe, allowing lipid droplets and lysosomes to be labelled simultaneously and with high specificity, being visualized readily through yellow and red fluorescence, using different excitation and detection channels

Heat shock protein inhibitor, preventing the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40, reducing thermotolerance of tumors in SCC VII tumor-containing mice

Novel activator of SIRT1, inducing autophagic cell death via the AMPK-mTOR-ULK complex and inducing mitophagy by the SIRT1-PINK1-Parkin pathway, downregulating 14-3-3γ, catalase, profilin-1, and HSP90α

Naturally occurring inhibitor of FOXO1a nuclear export

Novel and potent EZH2 inhibitor

Potent histamine H3 receptor antagonist