Novel specific pyruvate kinase M2 activator, promoting the formation of PKM2 tetramer, effectively blocking PKM2 nuclear translocation, and inhibiting the growth of tumour

Novel inhibitor of tubulin polymerization, arresting cells in the G2/M phase of the cell cycle, interferring with cancer cell migration and proliferation, and enhancing apoptotic cascades

Novel specific inhibitor of PDK4. binding to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid

Modulator of the N370S mutant form of glucocerebrosidase

Inhibitor of EWS-FLI1 oncoprotein in Ewing's Sarcoma

Novel KRAS Agonist, binding the GTP/GDP-binding pocket of KRAS, preventing the cleavage of GTP into GDP, leading to the accumulation of GTP-KRAS, an active form of KRAS

Novel cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 100 nM and 60.0 nM for h-cGAS and m-cGAS, respectively)

Novel potent inhibitor of Proprotein convertase subtilisin/kexin 9 (PCSK9), targeting the PCSK9/LDLR protein-protein interaction

First-in-Class Chitotriosidase (CHIT1) Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

Novel potent and selective inhibitor of ketohexokinase (KHK)

Novel potent dCTP Pyrophosphatase 1 (DCTPP1) inhibitor

Novel potent dCTP Pyrophosphatase 1 (DCTPP1) inhibitor

Novel potent inhibitor of IRAK1/4 and FLT3 with improved solubility, stability, and permeability properties suitable for in vivo utility

The first selective inhibitor of DAPK1

Idiotype-specific blocker of neuromyelitis opticaimmunoglobulin G (NMO-IgG) binding to aquaporin-4 (AQP4)

Novel serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2

A research chemical with highly selective dopaminergic stimulant and antibiotic properties.

Novel allosteric PTP4A3 inhibitor, increasing Emilin 1 gene expression

Novel potent auxin antagonist

Novel specific inhibitor of bacterial RecBCD helicase-nuclease DNA repair enzyme; Inhibitor of autotaxin (ATX, NPP2)

Novel YAP-TEAD Interaction Inhibitor, inhibiting TEAD activity, cell proliferation, and cell migration

Selective and Potent Inhibitor of Fibroblast Activation Protein and Prolyl Oligopeptidase

Novel cathepsin S inhibitor, enhancing oxaliplatin-induced apoptosis through upregulation of Bim expression

Novel irreversible transglutaminase 2 (TG2) inhibitor

Novel tissue transglutaminase (TG2) inhibitor

Appropriate clinical biomarker to recapitulate drug-drug interactions mediated by OATP inhibition

Novel destabilizer of the endosome membrane, enhancing the endosome-leakage activity of cell-penetrating peptides and facilitating the endosomal escape of macromolecules initially internalized by mammalian cells via endocytosis

Water soluble glyburide, inhibitor of the sulfonylurea receptor 1 (SUR1), regulating subunit of the ATP-sensitive potassium channels (KATP) in pancreatic beta cells

Cell-permeable, Irreversible, Non-cytotoxic Pan Caspase Inhibitor

Novel inhibitor of LRRK1, suppressing osteoclast function, but not osteoclast differentiation