Highly selective M1 positive allosteric modulator (PAM)

Novel S100P Inhibitor

Novel inducer of G2/M arrest with down-regulation of Cdc (Tyr15) and Cdc25C, and up-regulation of cyclin B1, phospho-Cdc2 (Thr161) and Aurora A/B

A HCV NS5A inhibitor

Novel SIRT6 inhibitor, reducing glycemia and improving oral glucose tolerance in unfed wild-type mice

Novel antitumor agent, inducing PKR-mediated apoptosis and synergizing with IFN

A potent positive allosteric modulator (PAM) on the three KAR subunits GluK1b, GluK2a, and GluK3a. BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold, and noticeably decreases desensitization kinetics (from 5.5 to 775 ms).

Dopamine antagonist, also having antihistaminic and anticholinergic properties

MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome

TAAR1 agonist, for the short-term treatment of obesity

A potent, selective and orally bioavailable c-Met inhibitor