Natural antibiotic, having diverse biological activities including broad-spectrum antibiosis against Bacteria and lower Eukarya, plant disease suppression, and enhancement of the insecticidal activity of Bacillus thuringiensis toxin against lepidopteran l

Potent, cell-permeable and irreversible caspase-1/5 inhibitor

Antagonist of D1 and D2 dopamine receptors.

Novel COX-2 inhibitor

Novel potentiator of KCNQ2 potassium channels

The first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Novel zinc sensor with a chloroalkane linker, reacting specifically with the engineered protein HaloTag, binding zinc ions with a threefold fluorescence enhancement

Gastroprotective agent for the treatment of peptic ulcer

Inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma

Potent, selective, and brain penetrating H2 receptor antagonist

Inducer of functional angiogenesis through increased H 2 S availability

Novel antidiabetic agent for the treatment of type 2 diabetes mellitus (DM)

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3)

Potassium channel opener

Selective nonpeptide, NK-2 receptor (NK-2R) antagonist

K-Channel opener (PCO) activating predominantly KATP channels in vitro to relax bladder detrusors

5-Lipoxygenase (5-LO) inhibitor

Non-steroidal pure antioestrogen

ATP-sensitive potassium channel-blocker; Eukalemic diuretic

Novel potent and highly selective inhibitor of wild-type and mutant versions of EZH2

Novel β-catenin/B-cell lymphoma 9 (BCL9) inhibitor, disrupting the β-catenin/BCL9 protein-protein interaction (PPI) with a Ki of 0.96 μM and without affecting the β-catenin/E-cadherin interaction in living cells, displaying good selectivity for β-catenin/

Novel potent and selective BRD4 bromodomain 1 (BD1) inhibitor

Novel potent and selective BRD4 bromodomain 1 (BD1) inhibitor

Novel dual mordulator of nNOS-PSD-95 interaction and GABA A receptor

Novel potent inhibitor of factor Xa (FXa)

Novel oral multitarget tumour growth inhibitor

Type III progesterone receptor antagonist with enhanced antiproliferative properties

Non-competitive AMPA receptor antagonist

Cell-permeable fluorometric zinc sensor

Novel ASCT2 inhibitor