Fluorogenic peptide substrate for a direct fluorometric assay of urokinase, tissue-type plasminogen activator, trypsin and thrombin

Novel Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist

Novel inhibitor of pro-HGF activation

Novel daul inhibitor of GSK-3β (IC 50 = 71 nM) and DYRK1A (IC 50 = 103 nM) with good blood-brain barrier penetrability, inhibiting hyperphosphorylation of tau protein in okadaic acid (OKA)-induced SH-SY5Y cells

Site specific inhibitor of tissue transglutaminase

Novel potent HDAC inhibitor with IC50 values for class I HDACs 1, 2, and 3 below 4 nM, and IC50 for HDAC6 at 6 nM.

ZDHHC (zinc finger Asp-His-His-Cys) substrate peptide, a 15-mer peptide sequence from KRas4a plus two tryptophan residues

Potassium channel opener

Vascular targeting agent (VTA)

Potent, orally active inhibitor of 5-lipoxygenase (5-LO)

Endothelin Receptor Antagonist

Novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than CPT-11 and SN38 at inhibiting topoismerase-1

Serotonin 5-HT3 receptor antagonist

Inhibitor of the nuclear division in germinating zoospore cysts of Phytophthora capsici via destruction of the microtubule cytoskeleton, and a consequent inhibition of mitosis

Novel USP10 inhibitor

Novel potent dual σ1/2 ligand (σ1 K i =5nM, σ2 K i =3nM), showing anti-allodynic in a model of neuropathic pain

Novel riboswitch activator, binding ZTP riboswitches, and activating transcription more strongly than ZMP in vitro

Novel potent ligand of σ2 receptor (K i =7nM)

Novel first-in-class inhibitor of BRD4 and EGFR kinase

Novel activator of JNK, binding directly to microtubules, inducing ERK-mediated mitotic arrest and subsequent apoptosis

Novel YycG inhibitor, significantly inhibited biofilm formation in static and dynamic conditions

Novel YycG inhibitor, inhibiting planktonic cells of E. faecalis, including the vancomycin- or linezolid-resistant strains

Novel inhibitor of Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin

Novel γ-lactam pyrazolidinone, targeting penicillin-binding proteins (PBPs) and incorporating a siderophore moiety to facilitate uptake into the periplasm, being effective against multidrug-resistant gram-negative Bacilli

Selective A 2A receptor agonist

Novel Proteasome Inhibitor, Enhancing Cisplatin Cytotoxicity in Cisplatin-Resistant Human Ovarian Cancer Cells, inducing cell cycle arrest on G2 phase in MCF-7 cells via ERα and PI3K/Akt pathways

DNA-intercalating dye as sensitive amyloid probe

Novel potent orexin 1 receptor (OX1R) antagonist

Water-soluble analog of YNT-707, acting as a potent orexin 1 receptor (OX1R) antagonist

Potent and selective microbicidal agent against wild type (wt) HIV-1, NNRTI-, NRTI-, PRI-resistant mutants