Novel inhibitor of airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease (COPD)

Novel potent inhibitor of osteoclastogenesis, suppressing both equilibrative nucleoside transporters and concentrative nucleoside transporters

Fluorescent substrate which can be hydrolyzed by the proteasome to release free AMC and the fluorescence of which is proportional to the proteasome activity

Natural immunosuppressive agent, effectively blocking T cell proliferation and survival while profoundly inhibiting pro-inflammatory IFNγ and IL-17 production by fully differentiated effector Th1 and Th17 cells, also acting as an estrogen receptor antagon

Novel potent and selective inhibitor of the cellular PDGF receptor kinase and PDGF receptor-induced cell proliferation

Agonist of TRPV1

Sunitinib analog, acting as a potential inhibitor for nucleoside diphosphate kinase (NDK) from Leishmania major (LmNDK)

Potent c-MET inhibitor

Novel potent c-MET inhibitor

Novel dual Inhibitor of repair enzymes 8-oxoguanine DNA glycosylase (OGG1) and human MutT Homolog 1 (NUDT1 or MTH1), increasing sensitivity of tumor cells to oxidative stress

Novel Nonsteroidal Inhibitor of Carbonic Anhydrase IX

Inhibitor of 17β-hydroxysteroid dehydrogenases (17β-HSDs)

Novel agonist of the tissue-protective erythropoietin (EPO) receptor, increasing FXN expression and EPOR phosphorylation

The first nonpeptidyl, selective activator of the tissue-protective EPOR/CD131 receptor

Antibiotic, being used as an antineoplastic agent and to induce diabetes in experimental animals

Metablite of the Streptomyces antibiotics streptothricin and streptolin

Potent natural modulator of human Toll-like receptor 7 (TLR7)

Novel activator of cellular ATG4B activity

Novel blocker of IL-17A binding to the IL-17A receptor (IL-17RA)

Novel inhibitor of the heterogeneous ribonuclear protein A18 (hnRNP A18)

Dual inhibitor of topoisomerase 1 and 2, inducing G(2) arrest in the absence of DNA damage. Inhibitor of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay

Novel Fatty Acid Binding Protein 5 (FABP5) Inhibitor

Novel Fatty Acid Binding Protein 5 (FABP5) Inhibitor

Novel covalent antagonist of hsSTING

Novel non-nucleotide STING agonist, demonstrating antitumor activity when dosed intratumorally in a syngeneic mouse model

Natural anti-feline infectious peritonitis virus (FIPV) agent, specifically targeting the 3CLpro of FIPV and inhibiting its replication

Novel RBP4 antagonist for treatment of Stargardt disease

Novel inhibitor of expression from canonical CREB response element-containing promoters

Natural inducer of G1 arrest in primary human esophageal epithelial cells but G2 arrest in immortalized cells

Novel human stem/progenitor cells proliferation activator, promoting survival and preserving stemness in human embryonic stem cells