Highly Potent and Selective Inhibitor of the Transcription Factor STAT5b

Novel cell-permeable selective STAT5a inhibitor prodrug, inhibiting tyrosine phosphorylation of STAT5a with selectivity over STAT5b in cultured human leukemia cells, and representing a valuable tool to define the non-redundant molecular functions of the t

Novel inhibitor of signal transducer and activator of transcription 3 (STAT3), inhibiting the proliferation of tumor cells harboring abnormal activation of STAT3, such as, MDA-MB-468, MDA-MB-231 and DU145

Novel inhibitor targeting the DNA-binding domain of STAT3, suppressing tumor growth, metastasis and STAT3 target gene expression in vivo

Novel potent and selective inhibitor of STAT3

Novel inhibitor of STAT3, targeting SH2 domain

Novel inhibitor of STAT3 signaling pathway

Novel STAT3 inhibitor, selectively inhibiting STAT3 phosphorylation and exhibiting potent antitumor activity

Anabolic-androgenic steroid (AAS), acting as an agonist of the androgen receptor (AR)

Novel Lipopeptide Antibiotic with Potent Antibacterial Activity against Multidrug-Resistant Bacteria

Cell permeable AKAP disruptor, selectively binding to PKA-RII and blocking the interaction of PKA-RI with AKAP

Novel tubulin-binding vascular disrupting agent (VDA)

Novel PARP-1 inhibitor, showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp

Highly selective FAAH>fatty acid amide hydrolase (FAAH) inhibitor

Novel selective NaV1.7 inhibitor, blocking the extracellular vestibule of the channel with an IC50 of 72 nM and greater than 200-fold selectivity over off-target sodium channel isoforms, NaV1.1-1.6 and NaV1.8

Novel potent A 1 R/A 2A R/H 3 R multitargeting ligand (MTL)

Novel potent A 1 R/A 2A R/H 3 R multitargeting ligand (MTL)

Seletive dopamine D3 receptors

Novel highly potent and soluble partial FXR agonist

Novel histamine H3 receptor ligand

Antiviral agent against LASV and a number of other viruses in the Arenaviridae family

Potent, direct, non-cytotoxic Arachidonate_5-lipoxygenase>5-lipoxygenase (5-LO) inhibitor

Novel histamine H3 receptor ligand

Novel potent mast cell (MC) activator, promoting de novo synthesis of cytokines and inducing the release of eicosanoids from human and mouse MCs

Novel inhibitor of the c-di-AMP synthetase DNA integrity scanning protein (DisA) in vitro

Novel potent mast cell (MC) activator, promoting de novo synthesis of cytokines and inducing the release of eicosanoids from human and mouse MCs

Novel potent mast cell (MC) activator, promoting de novo synthesis of cytokines and inducing the release of eicosanoids from human and mouse MCs

Novel somatostatin receptor subtype 5 antagonist, stimulating glucoseinduced GLP-1 secretion, reducing blood glucose in a gut- and GLP-1R-dependent manner

Novel potent sstr3 antagonist, showing to reduce glucose excursion in a mouse oGTT assay

Novel non-peptidic highly potent somatostatin receptor 3 (SSTR3) agonist