Novel potent inhibitor of quorum sensing (QS) pathways, strongly blocking agr-type QS in S. aureus

Novel fluorescent molecular rotor for the selective detection of the hybrid-conformation 22AG G-Quadruplex

Novel Nav1.7 channel blocker (IC 50 at 3.5±1.5 μM). being efficacious on chronic pain in mice

Novel reactive oxygen species (ROS) inducer, showing significant cytotoxicity in pancreatic cancer cells

Novel Heme Oxygenase-1 Inhibitor (HO-1 IC 50 =0.27μM; HO-2 IC 50 =0.46μM)

Selective PAR1 negative allosteric modulator

Novel class of bright near infrared window II (NIR-II, 1,000 - 1,700 nm) probe, being successfully used to achieve high spatial and temporal resolution imaging of hind limb vasculature, lymphatic system, and small tumor metastasis, as well as precise NIR-

Novel inverse agonist of 5-HT6 receptor

Y2/Y5 Neuropeptide Y receptor agonist, reducing food intake in normal-weight and obese individuals and the plasma levels of the hunger-promoting hormone ghrelin

Novel BBB-permeable substrate of pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA), acting as a selective class I HDAC inhibitor

Novel KMD5A inhibitor

Novel highly potent agonist of the apelin receptor (APJ) receptor (APJ cAMP EC50: human 0.023nM; rat 0.024nM; dog 0.030nM; monkey 0.080nM)

Natural phytotoxin, inducing monopolar spindle formation and suppressing proliferation of cancer cells

Novel inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis), suppressing bacterial cytotoxicity, biofilm formation and antibiotic resistance

Novel inhibitor of p53-MDM2 interaction

Bacterial siderophore, acting as an iron-chelating growth promoter for Pseudomonas aeruginosa

Novel suppressor of cancerous cell growth and proliferation

Novel potent inhibitor of collagen prolyl-4-hydroxylases (CP4H)

Inhibitor of cell death induced by oxidative stress and inhibitor of AB1-40 aggregation induced by Cu2+ ion

Novel selective FGF14:Nav1.6 PPI modulator

Novel Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitor

Novel potent anticancer agent, disturbing microtubule formation at the centrosomes and inhibiting the growth of tumors dose-dependently in the HCT116 human colon cancer xenograft model in vivo

Novel potent and selective CHEK2>Chk2 inhibitor

Novel Grp94-selective inhibitor PU-WS13 biotin probe

Natural heat shock protein 90 (Hsp90) inhibitor, potentiating the echinocandin drug caspofungin in caspofungin-resistant fungal pathogens, blocking the induction of caspofungin-responding genes required for the adaptation to cell wall stress through the c

Dual inhibitor of PDE3 and PDE4

Novel specific Hsp90b1 inhibitor

Hsp90α- and Hsp90ß-selective inhibitor

Novel specific inhibitor of tumor Hsp90

Hsp90α- and Hsp90ß-selective inhibitor