Novel dual inhibitor of dihydroceramide desaturase (dhCerDS) and acid ceramidase (ACDase)

Novel dual inhibitor of dihydroceramide desaturase (dhCerDS) and acid ceramidase (ACDase)

Potent fluorescent α4β1/α9β1 inhibitor

Novel metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator (NAM)

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS)

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS), showing significant reduction in tumor growth in mice

Novel potent inhibitor of p38 MAPK

Novel inhibitor of the tyrosine kinase BCR-ABL and platelet-derived growth factor receptor, inhibiting mitosis entry in acute myeloid leukemia cells via suppression of Aurora kinase A expression

Hsp90 N-terminal inhibitor

Potent anti-free radical agent, elevating glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lowering malonaldehyde (MDA) level in vivo in the Alzheimer's model

Novel potent selective androgen receptor modulator (SARM)

Inhibitor of Janus kinases

Novel potent DNA-alkylating agent, inhibiting TBP/DNA interaction

Prodrug of Racemetirosine, an inhibitor of tyrosine 3-monooxygenase

Novel inhibitor of PI3Kβ and PI3Kδ, inhibiting growth of PTEN deficient breast and prostate tumor

Potent and selective antagonist of 5-HT2A receptors

Efficient stabilizer of Mahoney procapsids

Novel Antiviral agent for Enterovirus D68

Novel inhibitor of HDL uptake induced by overexpression of scavenger receptor BI (SR-BI)

Novel scavenger receptor class B type I blocker

Novel Potent and Specific Ligand of r(CCUG)exp, Targeting r(CCUG) Repeats in Myotonic Dystrophy Type 2, Facilitating Degradation by RNA Quality Control Pathways

Second-Generation GluN2C- and GluN2D-selective positive allosteric modulator (PAM) of the N-methyl-d-aspartate (NMDA) receptor

Novel microtubule destabilizer

Novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo

Natural disrupter of DNA replication and transcription via DNA intercalation, reducing oxygen intake and carbohydrate metabolism and the excitability of muscle fibers, inhibiting the drug efflux pump P-glycoprotein

Potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor

Modulator of specific GABAA receptors via the benzodiazepine site on the GABAA receptor

Novel photodynamic antitumor agent

Novel multitarget anti-AD agent, significantly increasing in adult neurogenesis and remyelination through Prox1/NeuroD1 and Wnt/β-catenin pathways, demonstrating beneficial effects in preclinical models of AD

Novel potent inhibitor of quorum sensing (QS) pathways, strongly blocking agr-type QS in S. aureus