Novel inhibitor of phospholipase C (PLC) isozyme

Broad spectrum aminoglycoside antibiotic typically used for moderate-to-severe urinary tract infections or pyelonephritis

Gastroprotective agent, increasing the prostaglandin production in the gastric mucosa and accelerates ulcer healing

Novel Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2

Novel Potent and Specific Inhibitor of Placental Alkaline Phosphatase (PLAP; IC 50 = 32 nM), Targeting Tumor of the Female Reproductive Tract

Antilipidemic and antiplatelet agent

Potent inhibitor of HipA toxin, inhibiting E. coli persistence

Novel potent and specific β5i inhibitor

Novel highly potent and selective PKM2 inhibitor, blocking PKM2 mitochondrial translocation under nutritional stress and inhibits tumor growth in vivo

Novel selective inhibitor of protein kinase Cθ (PKCθ)

Novel Protein Kinase C-iota (PKC-ι) Inhibitor, Binding Post-kinase Domain Residues

Potent ligand to target the Y220C pocket, stabilizing Y220C

Inhibitor of topoisomerase II, intercalating into DNA and inducing topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity

Inhibitor of the acetylcholinesterase activity from bovine erythrocytes and electric eel

NSAID with better gastrointestinal (GI) tolerability

Natural nitric oxide (NO) production inhibitor

Novel potent in vitro and in vivo antifungal agent against azole-resistant Candida albicans

Antifungal antibiotic, showing inhibitory activity against fungi and yeasts, especially against Trichophyton

Antipsychotic prodrug, most notably used for schizophrenia

Inhibitor of PIP 4 Ks, efficiently killing transformed BJ cells, but not normal counterparts, displaying a strong selective lethality against Ras-activated or Ras-transformed cells

Antipsychotic agent

Novel potent PIM inhibitor

Potent, highly selective, and orally bioavailable inhibitor of PIM-1 kinases

Natural activator of cryptic biosynthetic gene clusters (BGC), also acting as a potent inhibitor of monoamine oxidase B

Novel PI3K inhibitor, displaying potent preclinical activity against multiple myeloma

Prodrug of GABA, used for treatment of neurogenic bladder in spinal and benign prostatic hyperplasia

Potent and selective beta2-adrenoceptor agonist

Novel Subtype-Selective PPARbeta/delta Agonist

Selective 5-HT4 receptor antagonist

Novel PI3K inhibitor, synergizing with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling.