Novel iNOS homodimerization inhibitor

Novel pan-human EGF receptor (HER) inhibitor

Hypobetalipoproteinemic and Lipid decreasing agent

Potent Activator of Vγ9Vδ2 T-Lymphocytes; HMBPP ananlog prodrug

Novel pan-inhibitor of KCa3.1/KCa2 channels

Antibiotic as a last-line therapy to treat infections caused by these life-threatening 'superbugs'

Novel activator of Adenosine monophosphate (AMP)-activated protein kinase (AMPK)

Used for the transfection of a broad variety of cell lines; Antimicrobial; Novel binding agent of diffusive gradients in thin-films (DGT) technique (PEI-DGT)

Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

Novel modulator of protein-protein interactions of the mitotic polo-like kinases, targeting KRAS mutant xenografts, indicate avenues, acting synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells

Novel macrocycle antibiotic with selective and potent activity against P. aeruginosa

Novel RNA polymerase I inhibitor, targeting ribosomal DNA G-quadruplexes, potently and selectively inhibiting cell growth by high-affinity binding to G4s in ribosomal DNA, impairing RNA polymerase I (Pol I) elongation, inducing a rapid inhibition of Pol I

Novel microtubule destabilizing natural product from the Podophyllum species

The first small-molecule approach capable of detecting and controlling engineered cell-cell outputs

Allosteric modulator of 5-HT(2C)R with no intrinsic agonist activity

Potent inhibitor of CDK2/cyclin A

Novel G Protein-Biased Cannabinoid 1 (CB1) Receptor Agonist

Cell-permeable analog of pifithrin-α, potently blocking p53-mediated expression of p21/WAF1 and apoptosis

Selective 5-HT1A serotonin receptor antagonist

Novel inhibitor of prenylated methylated protein methyl esterase (PMPMEase), a key enzyme in the reversible methylation/demethylation step in the protein prenylation pathway

Novel inhibitor of prenylated methylated protein methyl esterase (PMPMEase), a key enzyme in the reversible methylation/demethylation step in the protein prenylation pathway

Novel potent irriversible dual inhibitor of tubulin and epidermal growth factor receptor (EGFR), inducing the apoptosis of A549 cells in a dose- and time-dependent manner, along with decrease in mitochondrial membrane potential (MMP), production of ROS an

Novel inhibitor of β-catenin signaling, significantly reduced β-catenin activity in hepatoblastoma and several HCC cells

Potent anticancer tetrahydroisoquinoline alkaloid, being able to form a covalent bond with the amino group of a guanine in selected triplets of DNA duplexes and eventually give rise to double-strand breaks

Slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility

Novel polo-like kinase 1 (PLK1) inhibitor

Novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD)

Plk1 PBD-specific phosphopeptide inhibitor, effectively inhibiting mitotic progression and cell proliferation

Novel activator of AMPK, inducing apoptotic death in prostate cancer cells

Novel enhancer of Reactive Oxygen Species (ROS), depleting glutathione levels in analogy to piperlongumine but with reduced cell death