Novel HIV-1 entry inhibitor

Novel HIV-1 entry inhibitor

L-Tyrosine caged with photosensitive ortho-nitrobenzyl side chain

Biological Active Reagents

Potent and selective A1 adenosine receptor antagonist

Dual peroxisome proliferator-activated receptor gamma and alpha (PPARgamma and PPARalpha) agonist

Novel CXC chemokine receptor 2 (CXCR2) antagonist

Potent NaV1.7 blocker, being 5-10 fold more potent than NaV 1.2 and NaV 1.6

Potent and selective blocker of voltage-gated Nav1.7 sodium channels

Novel selective blocker of NaV1.7 with little affinity for NaV 1.2, 1.3, or 1.6, being more potent at human vs guinea pig NaV1.7

Novel selective NaV1.1 inhibitor, reducing visceral hypersensitivity

Potent suppressor of inducible nitric oxide synthase (iNOS; NOS II)

Natural DnaE1 blocker, inducing a DNA damage response in Mycobacterium tuberculosis (Mtb) and inhibiting growth by blocking the replicative DNA polymerase, DnaE1

Activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4

Inhibitor of extrinsic and intrinsic thrombin generation, inhibiting clot-bound and free (fluid-phase thrombin)

Antagonist of alpha-2 adrenergic receptors and inhibitor of the neuronal uptake of norepinephrine

Novel Gut-Restricted Inhibitor of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia

Triple reuptake inhibitor

Novel repeat-structure-specific DNA ligand, specifically binding slipped-CAG DNA intermediates of expansion mutations

Novel fluorescent probe for detection of endogenously produced Naph-O2˙– in living cells and tissues

Mixed agonist/antagonist opioid modulator, binding with high affinity to the MOR and KOR, and having relatively low affinity for the DOR

Novel highly selective antibacterial agent against Propionibacterium acnes

Novel potent full agonist for orexin receptor

Partial estrogen antagonist, inhibiting angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF), inducing oxidative stress, protein kinase C and calcium signaling

Electron donor and cofactor for many redox enzymes including nitric oxide synthetase

Coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage

Novel antiviral agent against the replication of influenza virus A/H3N2 subtype in Madin-Darby canine kidney (MDCK) cells

Derivative of loline

Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) combination for the treatment of multiple sclerosis (MS)-related moderate to severe spasticity

Alkylating agent, forming DNA adducts at the C-8 position in guanine, resulting in single strand breaks, demonstrating carcinogenic action