Deuterium labeled m6A used in important m6A physiological pathways related studies

Novel RNA labeling probe through both metabolic and enzyme-assisted manners

Glucokinase activator (GKA)

Competitive inhibitor of both SPHK1 and SPHK2

Novel potent and selective PROTAC degrader of BRD3/4

Bacterial RNA polymerase (RNAP) inhibitor

Inhibitor of the chaperonin activity of HSP60, correlating to LONP and LRP130 aggregation

Novel inducer of apoptosis in a Myc-dependent manner, inhibiting Myc-driven transformation and disrupting MYC-Max interaction

Novel potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V

Myotoxin II fragment

Novel inhibitor of zinc finger DHHC domain-containing (zDHHC) enzymes

Novel inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max

Novel inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max

Major thiol in most actinomycetes involved in mycothiol biosynthesis and mycothiol-dependent enzymes such as mycothiol-dependent formaldehyde dehydrogenase and mycothione reductase

Novel mitophagy activator

Novel GPR119 agonist with Anti-Diabetic Efficacy in db/db Mice

CNS-penetrant, selective restorer of injury- or disease-induced overproduction of proinflammatory cytokines towards homeostasis. Selective suppressor of beta amyloid (Aβ)-induced glia proinflammatory cytokine production

Novel potent and selective cathepsin K (Cat K) inhibitor

Novel potent mutant IDH1 R132H inhibitor

Novel potent and selective MCL-1 inhibitor

Novel potent MurA inhibitor

Novel potent multitarget ligand

Useful probe in the mapping of membrane proteins, such as ion channels and transports proteins, as well as enzymes and receptors.

Useful probe in the mapping of membrane proteins, such as ion channels and transports proteins, as well as enzymes and receptors.

Novel mitochondria-targeted photoactivatable real-time probe, being phototriggered by either UV (one-photon) or NIR (two-photon) light to form a fluorescent coumarin product and facilitate the release of drug payload

Novel mTOR inhibitor, exhibiting potent anticancer activities against four tumor cell lines, including MCF-7, HeLa, MGC-803, and C6, inducing cell death via apoptosis by targeting both mTORC1 and mTORC2 within cells and arrests the cell cycle of HeLa at t

Novel selective mTORC1 inhibitor, directly targeting class I glucose transporters

Novel selective inhibitor of mTORC1, yielding potent inhibition of glucose uptake

Novel potent dual inhibitor of mTOR and HDAC1

Novel Mithramycin A (MTM) 2'-oxime (MTMox) conjugate, displaying an 11-fold increase in plasma exposure and improved efficacy in an Ewing sarcoma xenograft