Potent and selective ligand of imidazoline 1 receptor (I 1 R)

Novel Two-in-One Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Novel highly selective inhibitor of the low-molecular-weight protein tyrosine phosphatase (LMPTP), being highly orally bioavailable and reversing obesity-induced diabetes in mice

Novel AI-2 quorum-sensing inhibitor, affecting the starvation response and reducing virulence in several Vibrio species, most likely by interfering with LuxPQ

Novel p75NTR antagonist

Novel Probe for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Negative control for LM11A-24

Novel Modulator of p75NTR-dependent motor neuron death

Novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2)

Novel inducer of biofilm dispersal, having a slower rate of NO release

Highly

Potent, selective, and orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO) activity, inhibiting vascular adhesion protein 1 (VAP-1) activity and decreasing the density of macrophages in inflamed atherosclerotic plaques in mice

Novel pan-inhibitor of sialyltransferase (ST)

The first fluorogenic dipeptide probe for

The first inhibitor of the catalytic activity of AChE and AChE-induced amyloid-beta aggregation protecting against reactive oxygen species

Lipid II binder, causing specific upregulation of the vancomycin-resistance associated gene vraX which is implicated in the cell wall stress stimulon that confers glycopeptide resistance

5HT-4 antagonist with moderate 5HT-3 antagonist properties

Novel Fused Benzodiazepine Hybrid Payload for Antibody-Drug Conjugate (ADC)

Natural capsid inhibitor

Novel inhibitor of the oncogenic Lin28-let-7 interaction

Potent positive inotropic agent, inhibiting myocardial cell apoptosis

Inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT), and phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT)

Novel inhibitor of AMA1–RON2 interaction, blocking merozoite invasion from schizont-infected RBCs; Cytochrome P450 inhibitor

Serotonin-norepinephrine-dopamine triple reuptake inhibitor (SNDRI); Anti-depressant

Natural precursor of histamine; reversible inhibitor of protein synthesis

Novel inhibitor of cystine stone formation for treatment of cystinuria

Novel S. typhimurium infection inhibitor on the activity of DUSP3, DUSP11, and DUSP27

Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects

Novel irreversible inhibitor of cell division cycle 25B, inhibiting human cancer cells via ROS generation

Novel non-secosteroidal vitamin D receptor (VDR) ligand