Potent PDZ domain peptide inhibitor that rescues CFTR activity

Novel potent and Subtype-Selective Positive Modulator of KCa2 Channels

Dual PDE3/4 inhibitor

Highly specific transglutaminase 2 (TG2) inhibitor

LTB4 inhibitor for the treatment of b-cell leukemias and lymphomas, potently inhibiting histamine, platelet activating factor,and 5-lipoxygenase

Novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the in

Novel highly potent dual amylin and calcitonin receptor agonist (DACRA), showing long-lasting improvement of food preference and body weight loss

Selective inhibitor of Protein_kinase_D1>protein kinase D (PKD); Inhibitor of cell adhesion and HIV; Inhibitor of herpes simplex virus type 1 replication

Novel Plk1 PBD inhibitor, showing a remarkable in vitro anticancer effect by inducing Plk1 delocalization, mitotic arrest, and apoptosis in HeLa cells

Novel histone deacetylase inhibitor

Novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages

Antibiotic, binding within the mRNA channel of the 30S subunit and inhibiting protein synthesis

Novel antimalarial agent, providing protection to malaria-infected mice

Novel mGlu4 ligand

Natural anti-inflammatory agent, inhibiting the NF-κB-mediated transactivation of a luciferase reporter gene, IL-6 production, and COX-2 expression

Natural anti-inflammatory agent, inhibiting the NF-κB-mediated transactivation of a luciferase reporter gene, IL-6 production, and COX-2 expression

Novel inhibitor of the interaction of the N-terminally truncated RXR

Novel inhibitor of the interaction of the N-terminally truncated RXR

Novel norditerpenoid inhibitor of testosterone-5α-reductase

Novel antagonist for proteinase-activated receptor 2 (PAR2)

Novel inhibitor of peptidoglycan synthesis targeting the lipid II precursor

Novel dual CLK1 and CLK3 inhibitor

Novel potent and selective inhibitor of PIM kinases

Potent, highly selective, and irreversible ABHD6 Inhibitor

Inhibitor of all three monoamine transporters

Novel irreversible β-Glucocerebrosidase modulator

Novel β-Glucocerebrosidase modulator, promoting dimerization of β-glucocerebrosidase and revealing an allosteric binding site, stabilizing wild-type and N370S mutant GCase and increases GCase abundance in patient-derived fibroblast cells

Selective modulator of GABAA receptors containing the α5 subunit

Potent vanilloid receptor (VR1) agonist

Potent TRPV1 agonist