Iminosugar, binding selectively to N370S glucocerebrosidase and restoring its correct conformation and, consequently, enhancing its activity

Novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice

Natural Stabilizer of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

Selective thromboxane A2 (TXA2) synthase inhibitor

Neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon, also acting as anticonvulsant

Novel potent hA2BAR antagonist (Ki = 3.66 nM)

ET B receptor agonist, showing anti-apoptotic activity and protecting neural cells in rats with cerebral ischemia

Inhibitor of IRE1 endoribonuclease activity, strongly inhibiting XBP-1 splicing in an in vivo model of acute endoplasmic reticulum stress.

Novel inhibitor of CDC25 phosphatases, actively against human cancer cells

Novel Orally Efficacious IRAK4 Inhibitor, Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma

Novel potent and selective degrader of IRAK3, inducing proteasome-dependent degradation of IRAK3 and showing both CRBN and IRAK3 binding for activity

Novel interleukin-1 (IL-I) receptor-associated kinase (IRAK) modulator

NIR-II cyanine dye for cancer treatment and diagnosis

Novel potent inverse agonist of the chemokine receptor CXCR4, preventing CXCL12-mediated chemotaxis and triggering apoptosis in a panel of 18 cell lines and primary cultures, with superior mobilizing properties in vivo

Sulfasalazine analog, releasing 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract

Novel inhibitor of protein-protein interaction (PPI), targeting integrin αvβ3-osteopontin interface, blocking OC maturation from murine bone marrow-derived macrophages, as well as the resorptive function of OCs, impairing downstream signaling of integrin

Irreversible and nonselective Monoamine_oxidase_inhibitor>monoamine oxidase inhibitor (MAOI)

Inhibitor of the uPAR·uPA protein-protein interaction, blocking cancer cell invasion

Novel inhibitor of glioblastoma multiforme (GBM), inhibiting cell viability of low-passage patient-derived GBM spheroids, blocking tube-formation of endothelial cells in Matrigel, showing no effect on primary hematopoietic CD34+ progenitor spheroids or as

Natural inhibitor of the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor, binding Sec61α to Inhibit Protein Translocation

Natural toxic furanoterpenoid found in mold-damaged sweet potatoes

Orally bioavailable inhibitor of Hedgehog signaling, inhibiting tumor initiation and metastasis in pancreatic cancer

Muscarinic Acetylcholine Receptor Hybrid Ligand, possessing noticeable M2/M4 mAChR selectivity

Novel inhibitor of the plant inositol phosphorylceramide synthase ((IPCS), demonstrating herbicidal activity

Selective monoamine oxidase A inhibitor

Novel antifungal agent, exhibiting broad spectrum and potent activity against 12 kinds of clinically pathogenic fungi

Novel Potent Fungal-Selective Inhibitor of Mitochondrial Cytochrome bc1

Natural Activator of Programmed Cell Death, leading to membrane damage, mitochondria alteration, chromatin condensation, and ROS accumulation

Inhibitor of both topoisomerase I and II via intercalating DNA helix

Natural potent inhibitor of H. pylori DHODH, having greater efficacy for treatment of H. pylori infection