Novel inhibitor of MAGE-A11 with robust activity in TR-FRET for disrupting MAGE-A11:PCF11 interaction (IC50 0.40 μM)

Unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1), also inhibiting HIV-2

Novel inhibitor of MAGE-A11 with robust activity in TR-FRET for disrupting MAGE-A11:PCF11 interactionm being cell permeable and having improved activity in the TR-FRET assay (IC50 0.13 µM)

Novel inhibitor of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 on microglia, exhibiting anti-inflammatory activity through ER-stress-mediated autophagy, significantly inducing the conversion ratio of LC3 II/I and

Fluoroquinolone antibiotic, acting as antibacterial, antineoplastic, anti-Infective agents, Inhibiting DNA-gyrase and topoisomerase

Potent broad spectrm fluoroquinolone antibiotic

Novel in situ tetrazine ligation reactive silicon-rhodamine dye

Novel selective SIRT3 inhibitor, exhibiting SIRT3 inhibitory selectivity with IC50 value of 7.2 µM over SIRT1 (32.6 µM) and SIRT2 (33.5 µM), showing potent inhibitory activity against a group of MLLr leukemic cell lines

Potent and selective inhibitor of SIRT2

Novel SIRT1 inhibitor, inducing apoptosis in HCT116 human colon carcinoma cells partially by activating p53

Novel SIRT1 Inhibitor, showing potent effect on prostate cancer cell line

First-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, normalizing sirtuin 1 levels and improving cognition in an Alzheimer's disease mouse model

Novel SIRT1 Activator

Novel farnesoid X receptor antagonist

Novel D2/5-HT2A Receptor Dual Antagonist

Antioxidant and antimicrobial agent, counteracting mitochondrial oxidative stress in cardiomyocytes

Peroxisome proliferator

Novel COX-I and COX-II inhibitor with four times higher solubility in physiological media and a lower melting enthalpy than ibuprofen

Silicon-Containing GABA Derivative, Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects

Silicon-Containing GABA Derivative, Treating Neuropathic Pain without Central-Nervous-System-Related Side Effects

Novel Complement Factor C1 Inhibitor

Novel direct HIV-1 Nef antagonist with antiretroviral activity

Novel cognitive enhancer; Nootropic agent

Highly Potent and Peripheral Nervous System-Restricted KOR Agonist

Inhibitor of shp2 protein tyrosine phosphatase (PTP)

Antineoplastic antibiotic

Cystathione gamma lyase (CSE) inhibitor, inhibiting H2S production and L-cysteine-induced relaxation of rat aortic rings ex vivo

Novel potent stabilizing ligand for FKBP-derived destabilizing domains

Novel Inhibitor of Phospho-STAT3 Through Induction of Protein Tyrosine Phosphatase PTPN6

Selective inhibitor of cancer cell growth, exerting chemoprevention activity without evidence of toxicity