Cytochrome P450 14α-demethylase inhibitor, also acting as a BuChE-IDO1 inhibitor

Novel serotonin reuptake inhibitor

Novel mitochondrial KIM-1 receptor modulator to be specifically internalized by renal tubular epithelial cells via KIM-1 receptor-mediated endocytosis and then actively distributed in mitochondria under the effect of TPP, effectively ameliorating injured

Selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A) that prolong the benefit of eIF2α phosphorylation, thereby protecting cells from proteostatic defects

Novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID), inhibiting colorectal cancer (CRC) growth via the inhibition of the cell cycle in G1 and G2/M phases and reduces the cell cycle markers like cyclin E1 and B1 in a dose dependent manner

Sentrin-specific protease 1 (SENP1) inhibitor

Novel potent antagonist of the Hedgehog pathway

Novel Wnt inhibitor/Axin stabilizer

Novel S100B inhibitor

Novel AkaLumine analog, acting asa NIR emission luciferin with the enhanced solubility in water

Novel potent inhibitor of the enzyme soluble epoxide hydrolase (sEH)

Novel Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

Antagonist of gamma-aminobutyric acid A (GABA A ) receptor and cholinergic agent

Novel open-ring metabolite of rapamycin derivative

Natural plant growth inhibitor

Highly selective human tachykinin NK1 receptor antagonist

Potent antiproliferative agent, binding to the “colchicine binding site” on tubulin and inhibiting tubulin polymerization in vitro

Novel inhibitor of sterol 14a-demethylases (CYP51)

Selective 5-HT2B/2C receptor antagonist

Novel immunostimulatory monosaccharidic lipid A analog, down-regulating TNF-alpha and IL-6 production and priming secretion of G-CSF and IL-1 beta

Novel inhibitor of the Golgi complex (Vrg4); Antifungal

Selective, surmountable antagonist for 5-HT4 receptors

Potent inhibitor of MMP-2, -3, -9, -8, -13, and -14

Novel irriversible selective PDI inhibitor, selectively labeling protein disulfide isomerase and inhibiting its enzymatic activity, showing unique cytotoxicity in cells derived from multiple myeloma

NRTI-drug pair of zidovudine (AZT)-didanosine (ddI), being highly cytotoxic and mutagenic

Novel inhibitor of nNOS-PSD-95 interaction, exhibiting neuroprotective activities in NMDA-induced or Oxygen and glucose deprivation (OGD)-induced neuronal damage in primary cortical neurons cultures, and ameliorating focal cerebral ischemic damage in rats

Novel dual acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB)

Novel Inhibitor of p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs) with the IC50 values of 140, 910 and 17.5 nmol/L against MDM2, HDAC1, and HDAC6, respectively, showing the tumor growth inhibition (TGI) in the A549 xenograf

Selective, ATP-competitive p38

Novel inhibitor of SARS-CoV-2 main protease (MPro)