Novel inhibitor of WDR5-MLL1 interaction

Novel selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1)

Potent HCV NS5A inhibitor

p38 MAPK inhibitor, supressing p38 phosphorylation and LPS-induced TNF-α production in macrophages

Novel protein cross-linking agent

Novel antileishmanial agent, against both intracellular Leishmania donovani and intracellular Leishmania amazonensis and displaying dose-dependent reduction of liver parasitemia

Novel ERG/DNA binding inhibitor, targeting the DNA-binding activity of the human ERG transcription factor

Novel tyrosine kinase inhibitor for drug resistant T315I mutant BCR-ABL

Biological Active Reagents

Novel selective ionotropic glutamate receptor 5 (iGluR5) antagonist

Novel glucagon analog for diabetic hypoglycemia therapy

Novel PROTAC targeting drug-resistant BCR-ABL

Proteolysis targeting chimeras (PROTAC), acting as a degrader of oncogenic BCR-ABL

Proteolysis targeting chimeras (PROTAC), acting as a degrader of oncogenic BCR-ABL

An impurity formed in Darapladib production

Potent Selective serotonin reuptake inhibitor (SSRI)

Novel inhibitor of L,L-diaminopimelate aminotransferase (DapL)

Potent and selective fluorescent adenosine A1 receptor agonist

Lipid bilayer modulator which likely inserts into lipid bilayers in the headgroup region, alters their structure and phase behavior, thins the bilayer and fluidizes it, allowing even saturated lipid to form fluid bilayers

Novel potent Bax inhibitor, showing concentration-dependent inhibition of liposome permeabilization with improved activity in vitro

Widely used fluorescent detector of nitric oxide in culture medium, tissue sections and biopsy cells

Selective inhibitor of human DPP7

Novel selective and potent DPP7 inhibitor with a DPP7 IC50 value of 480 pM

Novel inhibitor of SET7/9

Novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice

Novel dual extracellular signaling-related kinase (ERK)/PI3K inhibitor

Novel direct AMPK agonist, showing potential anti-cancer activity via inducing apoptosis, cell cycle arrest, suppressing glycolysis and cholesterol synthesis after activation of AMPK in gefitinib-resistant H1975 cells

Novel ERK2 inhibitor

Novel potent and selective agonist of dopamine D 3 receptor (D 3 R; Ki = 5.72 nM)

Novel potent and selective agonist of dopamine D 2 receptor (D 2 R; K i = 4.58 nM)