Novel potent PD-1/PD-L1 antagonist (IC50 of 16.17 nM), activating the antitumor immunity of T cells efficiently in PBMCs

Novel inhibitor of PD-I/PD-L1 interaction to be used as a negative immune checkpoint regulatory and antineoplastic agent

Novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9)

Novel PCSK9 mRNA translation inhibitor

Novel PCSK9 mRNA translation inhibitor

Novel modulator of proprotein convertase subtilisin kexin like type 9 (PCSK9)

Novel potent dopamine D3R antagonist

Novel potent and selective dopamine D3R partial agonist

Novel potent dopamine D3R agonist (Ki=4.1nM)

Highly selective α1L adrenaline receptor agonist

Potent antagonist of the series disrupting EphA2-ephrinA1 interaction, blocking EphA2 phosphorylation in prostate cancer cells at low

Organoselenium compound with antidepressant-like and memory enhancer actions

Novel α7 nAChR weak partial agonist, showing antinociceptive and anti-inflammatory properties

Novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) binding and not dire

Novel Chelator for Cu-64

Non-dioxin-like (NDL) congener

Water-soluble novel potential COX-2 inhibitor

Potent tubulin-binding agent with anti-tumor efficacy in hematologic cancers

Novel calcineurin inhibitor in the C. albicans cells, enhancing susceptibility of the cells

Novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein sub

Novel αvβ3 inhibitor, showing excellent efficacy in a glioblastoma multiforme (GBM) mouse model

Pyridobenzimidazole infraluciferin, an analog of D-luciferin, increasing bioluminescence activity while maintaining nIR bioluminescence

Novel enhancer of Th1 type cytokine production and primary T cell activation

Novel Inhibitor of Parasite Proliferation of Asexual Blood Stage P. falciparum Parasites

Novel Inhibitor of Parasite Proliferation of Asexual Blood Stage P. falciparum Parasites

Novel potent glucosidase inhibitor, suppressing HCV virion assembly and secretion, potently inhibiting DENV infection in vitro

Novel potent inhibitor of

Partial agonist at GABAA benzodiazepine receptors with sedative and anxiolytic effects

Novel antiviral agent, potently against Rabies virus (RABV) targeting host-rabies virus protein-protein interactions

Natural ent-kaurane diterpenoid, markedly stimulates the expression of NKG2D ligands on hepatocellular carcinoma (HCC) cells, considerably enhancing their recognition and lysis by NK cells, covalently inhibiting peroxiredoxins I/II (Prxs-I/II) catalytic a