Novel potent inhibitor of the AAA+ ATPase p97

Novel potent inhibitor of the AAA+ ATPase p97

Neuroprotective agent, protecting ventral horn spinal cord motor neurons from cell death

Novel bFGF antagonist peptide, inhibiting breast cancer cell growth

Novel inhibitor of atherogenesis and diabetes, significantly and specifically inhibiting αD-CEP binding

Novel reactivator of mutant p53, fuctioning as a zinc metallochaperone (ZMC) with diminished copper binding that functions as a chemotherapy and radiation sensitizer

Novel modulator of p53 activity, arresting at G2/M phase inducing delay of cell cycle progression

Selective spleen tyrosine kinase (SYK) inhibitor, suppressing leukocyte immune function and inflammation, and leading to a reduction in arthritis score and attenuated histological damage

Novel P2Y1 Antagonist

Second-generation active site-targeted covalent irreversible inhibitor of USP7

Novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein

Novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein

Novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein

Novel p18(INK4C) inhibitor

δ-Opioid receptor agonist

Synthetic hormone with anabolic and androgenic properties

Antagonist of cell-surface heparan sulfate and heparin-protein interactions, reducing tau hyperphosphorylation and mitigating or delaying neuronal defects in tauopathies, including Alzheimer's disease

Vasodilator and β-adrenoreceptor agonist

Novel sulindac derivative; anti-inflammatory and anti-cancer agent

Novel inducer of differentiation in all six AML cell lines

Novel inhibitor of human cathepsin L

Novel inhibitor of the bromodomain and extra terminal domain (BET) bromodomain family member BRD4(1)

Novel potent inhibitor of GVIA iPLA2 with little or no inhibition against GIVA cPLA2 (XI(50) = 0.0073 and >0.91, respectively)

PPARalpha/gamma agonist

Novel dual inhibitor of the p53 interaction with MDM2 and MDMX

Potent inhibitor of PANC-1 cell migration and MYPT1 phosphorylation

Novel selective Ligand for the Orexin 2 Receptor (OX2R)

Brain penetrant, selective and high affinity OX1R antagonist

Novel anthelmintic agent

Novel anthelmintic agent, immobilising whipworm and reducing the ability of embryonated T. muris eggs to establish infection in the mouse host in vivo