Prodrug of QVO, being quickly converted to QVO in mice and rats following administration, ameliorating hyperglycemia, and suppressing hepatic gluconeogenesis and activating AMPK signaling pathway in the liver tissues

The first Ang IV-analogue being able to abolish IRAP-availability completely at the cell surface in vitro

Selective inhibitor of the funny channel pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the myocardium

First-in-class iodothyronine deiodinase type 3 (DIO3) inhibitor, demonstratig attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI)

Novel highly potent, orally bioavailable hepatitis C virus (HCV) entry inhibitor

Novel, potent, selective, and BBB-permeable P2X7 antagonist

Novel neuroprotective agent

Novel PP2A ligand, protecting against memory impairment and focal cerebral ischemia in mice

Novel selective HDAC6 inhibitor

Novel Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitor, showing a remarkably low toxicity both in vitro and in vivo and increasing the function of regulatory T cells (Tregs) at well-tolerated concentrations

Novel highly potent (EC 50 = 1.6 nM) aryl hydrocarbon receptor (AhR) agonist with high affinity (K i = 88 nM)

Novel degrader of CRABP proteins

Novel Potent and Selective A3 Antagonist

Unique topoisomerase inhibitor, showing significant growth-inhibitory effects against large-cell lung cancer (Lu-116) and gastric adenocarcinoma (St-4)

Distinct IKur blocker

Novel inhibitor of COX and neutrophil migration

Novel prodrug of potent IspH inhibitor, killing clinical isolates of several multidrug-resistant bacteria, including those from the genera Acinetobacter, Pseudomonas, Klebsiella, Enterobacter, Vibrio, Shigella, Salmonella, Yersinia, Mycobacterium and Baci

Biological Active Reagents

Inhibitor of the cellulose biosynthesis, inhibiting anisotropic cell expansion resulting in a severely swollen and stunted growth phenotype

Natural genistein derivetive with antibacterial and antifungal activities

P2X-purinoceptor antagonist

Natural antibacterial agent with cytotoxicity and hemolytic properties against a larger panel of Gram-negative bacteria

Natural essential oil, showing activity against T. muris

Potent inotropic agent, inhibiting both PDE3 and PDE4

Iminosugar, binding selectively to N370S glucocerebrosidase and restoring its correct conformation and, consequently, enhancing its activity

Novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice

Natural Stabilizer of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

Selective thromboxane A2 (TXA2) synthase inhibitor

Neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon, also acting as anticonvulsant

Novel potent hA2BAR antagonist (Ki = 3.66 nM)