Novel Nonsteroidal Negative Allosteric Modulator of Follicle-Stimulating Hormone Receptor (FSHR)

The first selective dual-target inhibitor of ERK1 and ERK5

Novel PDE10 inhibitor, reducing oncogenic β-catenin, suppressing TCF/LEF transcription

Inhibitor of semen-derived amyloid fibril formation, blocking fibril-mediated enhancement of HIV-1 infection

Novel Inhibitor of EGF-EGFR Interactions

Nonselective agonist of all adrenergic receptors, including the major subtypes alpha1, alpha2, ß1, ß2, and ß3

Active iron-chelating metabolite of dexrazoxane

Poly(ADP-Ribose) Glycohydrolase (PARG) inhibitor

Novel soluble analog of FiVe1

Novel antibiotic adjuvant, exhibiting as high as 4096-fold potentiation of multiple classes of antibiotics toward critical Gram-negative superbugs

Novel antibiotic adjuvant, exhibiting as high as 4096-fold potentiation of multiple classes of antibiotics toward critical Gram-negative superbugs

Novel Potent Mutant p53 Rescuing Agent

Antidepressant and anxiolytic agent, binding to peripheral-type benzodiazepine receptors that interact allosterically with GABA receptors as an agonist to produce inhibitory effects

Novel sheddase inhibitor, inhibiting the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity

Novel inhibitor of ClpXP complexes, causing extremely rapid dissociation of ClpXP complexes, preventing ClpX rebinding following spontaneous dissociation

Novel Hsp40-Hsp70 chaperone complex inhibitor, inhibiting the Hsp40-stimulated ATPase activity of the Hsp70 chaperone, with a K i of ~10 μM

Potential antidepressant and anti-Parkinson agent

Potential antidepressant and anti-Parkinson agent

Novel potent inhibitor of the MDM2-p53 interaction

Novel selective USP8 inhibitor (USP8 IC50 2.1 μM; USP7 >50μM)

Novel selective HDAC6 inhibitor, showing 260-fold selectivity towards HDAC6 vs other HDACs

Novel potent activator of pan-AMPK, enhancing AMPK phosphorylation by upstream kinase LKB1 and protecting AMPK complex against dephosphorylation by PP2C

Novel Inhibitor of BRD4-Driven Nucleoporin NUP210 Expression, Attenuating Colorectal Cancer Growth

Novel potent and selective LpxC inhibitor

Antipsychotic, targeting the dopamine D2 receptor

Novel Inhibitor of Cellulose Synthesis

Analgesic, antipyretic, and anti-inflammatory agent

Selective Caspase-3 inhibitor

Highly photodurable and blue-laser excitable fluorescent amino acid. acting as a highly fluorescent probe after being incorporated into specific positions of various antibodies, receptors, and enzymes

Novel Acetyl-CoA Carboxylase 2 (ACC2) Selective Inhibitor, Improving Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways