3-(4-Pyridyl)|cas 7272-84-6|DC Chemicals

Cas No.:	7272-84-6
Chemical Name:	3-(4-pyridinyl)-1H-Indole
Synonyms:	3-(4-pyridinyl)-1H-Indole;3-(4-Pyridyl)indole;rockout;4-(3-indolyl)-pyridine;3--indol;3-(PYRIDIN-4-YL)INDOLE;3-(pyridin-4-yl)-1H-indole;3-(4-Pyridyl)-1H-indole
SMILES:	N1C=CC(C2C3C(=CC=CC=3)NC=2)=CC=1
Formula:	C₁₃H₁₀N₂
M.Wt:	194.231902599335
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC72592	Zelasudil	Zelasudil is a Rho-associated coiled-coil kinase (ROCK) inhibitor with a specific binding affinity for ROCK2, a key enzyme in the Rho/ROCK signaling pathway. This pathway plays a critical role in regulating cellular processes such as cytoskeletal organization, cell motility, smooth muscle contraction, and gene expression. By selectively inhibiting ROCK2, Zelasudil modulates these processes, offering therapeutic potential for a variety of diseases characterized by fibrosis, inflammation, and vascular dysfunction, including pulmonary fibrosis, glaucoma, and cardiovascular diseases.
DC45762	Y-27632	Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
DC10167	ZINC00881524	ZINC00881524 is a ROCK inhibitor.
DC8567	3-(4-Pyridyl)	3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay