Shield-1|CAS 914805-33-7|DC Chemicals

Cas No.:	914805-33-7
Chemical Name:	Shield-1
Synonyms:	Shield-1 Tosylate;(S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Tosylate;(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate (ACI);Shield 1;Shield-1
SMILES:	[C@@H](C1C=C(OC)C(OC)=C(OC)C=1)(CC)C(N1CCCC[C@H]1C(=O)O[C@@H](C1C=CC=C(OCCN2CCOCC2)C=1)CCC1C=CC(OC)=C(OC)C=1)=O
Formula:	C₄₂H₅₆N₂O₁₀
M.Wt:	748.901453018188
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein[1][2].

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