SC-99 |CAS 882290-02-0|DC Chemicals

Cas No.:	882290-02-0
Chemical Name:	(E)-N-(3-chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
Synonyms:	STAT3 inhibitor SC99
SMILES:	N#C/C(C(C1=CC=C(Cl)C=C1)=O)=N\NC2=CC=C(F)C(Cl)=C2
Formula:	C₁₅H₈Cl₂FN₃O
M.Wt:	336.15
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src; inhibits STAT3 phosphorylation, dimerization and nuclear translocation, downregulates STAT3-modulated gene expression and induces MM cell apoptosis; delays tumor growth in MM xenograft models (30mg/kg); orally active.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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