Merck60| CAS 849234-64-6

Cas No.:	849234-64-6
Chemical Name:	BRD-6929
Synonyms:	Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]-;BRD-6929;4-(Acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]benzamide (ACI);4-Acetamido-N-[2-amino-5-(thien-2-yl)phenyl]benzamide;JQ 12;Merck 60
SMILES:	O=C(C1C=CC(NC(C)=O)=CC=1)NC1C(N)=CC=C(C2=CC=CS2)C=1
Formula:	C₁₉H₁₇N₃O₂S
M.Wt:	351.422182798386
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Merck60 (BRD 6929, Compound-60) is a potent, selective and brain-penetrant inhibitor of HDAC1 and HDAC2 with IC50 of 1 nM and 8 nM respectively; displays 50-400 fold selectivity over class I HDAC3 (IC50 = 458 nM) and no appreciable inhibition of HDAC8 or of the class II HDACs (IC50>30 uM); alters gene expression in brain circuits involved in mood regulation, improves mood-related behaviors in mice.

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