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Israpafant

  Cat. No.:  DC22896   Featured
Chemical Structure
117279-73-9
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More than 5000 active chemicals with high quality for research!
Field of application
Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 117279-73-9
Chemical Name: 4-(2-chlorophenyl)-2-(4-isobutylphenethyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Synonyms: Y-24180;Y24180;Y 24180
SMILES: CC1C2=NN=C(N2C3=C(C=C(S3)CCC4=CC=C(C=C4)CC(C)C)C(=N1)C5=CC=CC=C5Cl)C
Formula: C28H29ClN4S
M.Wt: 489.074
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication: 1. Takehara S, et al. Prostaglandins. 1990 Dec;40(6):571-83. 2. Kagoshima M, et al. Pharmacology. 1997 May;54(5):261-70. 3. Yamaguchi S, et al. Inflamm Res. 2000 Nov;49(11):584-90.
Description: Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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