Tie-2 inhibitor 7|cas 1020412-97-8|DC Chemicals

Cas No.:	1020412-97-8
Chemical Name:	5-[4-[[[2-[[(1S)-1-Cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]-3-pyridinecarboxylic acid
Synonyms:	Tie2 inhibitor,Tie inhibitor 7
SMILES:	C1=NC=C(C2=CC=C(CN(CC(N[C@@H](C3CCCCC3)C)=O)C(OC3=CC=C(C)C=C3)=O)C=C2)C=C1C(O)=O
Formula:	C₃₁H₂₉N₃O₅
M.Wt:	523.6
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Tie-2 Inhibitor 7 can permeate the cell (IC50= 1μM) and inhibit endothelial cell tube formation. Research shows that it can block the Tie-2 ligand, Ang-1 (angiopoietin), which induces Tie-2 autophosphorylation and block its downstream signaling with an IC50= 0.3 μM. Vascular leakage, suppression of endothelial apoptosis, and vessel regression are strongly inhibited by Ang-1. The Tie-2 receptor plays a crucial role in the normal and pathologic vascular development of epithelial cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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