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Golcadomide(CC-99282)

  Cat. No.:  DC72103   Featured
Chemical Structure
2379572-34-4
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More than 5000 active chemicals with high quality for research!
Field of application
Golcadomide (CC-99282) is a highly potent and orally bioavailable CRBN E3 ligase modulator (CELMoD). It interacts with the CRL4 CRBN E3 ubiquitin ligase substrate receptor CRBN, facilitating the recruitment and ubiquitin-mediated proteasomal degradation of the transcription factors Ikaros and Aiolos. Golcadomide holds significant promise for research in cancer-related areas, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL).
Cas No.: 2379572-34-4
Chemical Name: Golcadomide
Synonyms: (S)-2-(2,6-Dioxopiperidin-3-yl)-4-[[2-fluoro-4-[(3-morpholinoazetidin-1-yl)methyl]benzyl]amino]isoindoline-1,3-dione;CC 1007548;Golcadomide
SMILES: C12=C(C(N([C@H]3CCC(NC3=O)=O)C1=O)=O)C(NCC1=C(F)C=C(C=C1)CN1CC(C1)N1CCOCC1)=CC=C2
Formula: C28H30FN5O5
M.Wt: 535.57
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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