Potent pan KDM Inhibitor, inhibiting KDM2A, KDM7A, KDM7B, KDM4A, KDM4C, and KDM5A

Less active trans-isomer of NCB-0846, acting as the negative control for NCB-0846, showing 13-fold weaker TNIK enzyme-inhibitory activity

First-in-class, potent, and selective Lactate dehydrogenase inhibitor

First-in-class, potent, and selective Lactate dehydrogenase inhibitor

Novel inhibitor of methionine aminopeptidase 2 (MetAP2)

M. tuberculosis Dihydrofolate Reductase Inhibitor

Novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy

Potent and selective 5-HT2A receptor agonist

Potent agonist of the human 5-HT2A and 5-HT2C receptors

Novel CD4-mimetic HIV-1 entry inhibitor

Novel HIV-1 entry inhibitor

Novel HIV-1 entry inhibitor

L-Tyrosine caged with photosensitive ortho-nitrobenzyl side chain

Biological Active Reagents

Potent and selective A1 adenosine receptor antagonist

Dual peroxisome proliferator-activated receptor gamma and alpha (PPARgamma and PPARalpha) agonist

Novel CXC chemokine receptor 2 (CXCR2) antagonist

Potent NaV1.7 blocker, being 5-10 fold more potent than NaV 1.2 and NaV 1.6

Potent and selective blocker of voltage-gated Nav1.7 sodium channels

Novel selective blocker of NaV1.7 with little affinity for NaV 1.2, 1.3, or 1.6, being more potent at human vs guinea pig NaV1.7

Novel selective NaV1.1 inhibitor, reducing visceral hypersensitivity

Potent suppressor of inducible nitric oxide synthase (iNOS; NOS II)

Natural DnaE1 blocker, inducing a DNA damage response in Mycobacterium tuberculosis (Mtb) and inhibiting growth by blocking the replicative DNA polymerase, DnaE1

Activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4

Inhibitor of extrinsic and intrinsic thrombin generation, inhibiting clot-bound and free (fluid-phase thrombin)

Antagonist of alpha-2 adrenergic receptors and inhibitor of the neuronal uptake of norepinephrine

Novel Gut-Restricted Inhibitor of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia

Triple reuptake inhibitor

Novel repeat-structure-specific DNA ligand, specifically binding slipped-CAG DNA intermediates of expansion mutations

Novel fluorescent probe for detection of endogenously produced Naph-O2˙– in living cells and tissues