Noradrenergic and specific serotonergic antidepressant (NaSSA)

Novel inhibitor of GATA family proteins, targeting the DNA-binding activity of GATA3 and other members of the GATA family, inhibiting the interaction between GATA3 and SOX4, significantly suppressing Th2 cell differentiation, without impairing Th1 cell di

5-HT2 serotonin receptor antagonist

Novel potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K)

mGluR5 inhibitor

Novel selective caspase 8 activator, potentiating TRAIL-induced cell death

Novel inhibitor of exocytosis and endosomal recycling in both plant and human cells, binding to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, enhancing plant vacuolar trafficking

Novel diacylglycerol (DAG) photoswitch, enabling efficient control of TRPC3 by light

Negative control for DO34, not inhibiting DAGL

Novel potent PRMT5 specific inhibitor, specifically blocking KLF4-mediated transcription and cell survival, suppressing breast tumor progression

Novel PIP4Kγ inhibitor, increasing cellular levels of three lipids that are involved in an important process to clean up damaged proteins in cells

Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models

Cytotoxicity inhibitor associated with mutant Huntingtin protein expression

Novel specific pyruvate kinase M2 activator, promoting the formation of PKM2 tetramer, effectively blocking PKM2 nuclear translocation, and inhibiting the growth of tumour

Novel inhibitor of tubulin polymerization, arresting cells in the G2/M phase of the cell cycle, interferring with cancer cell migration and proliferation, and enhancing apoptotic cascades

Novel specific inhibitor of PDK4. binding to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid

Modulator of the N370S mutant form of glucocerebrosidase

Inhibitor of EWS-FLI1 oncoprotein in Ewing's Sarcoma

Novel KRAS Agonist, binding the GTP/GDP-binding pocket of KRAS, preventing the cleavage of GTP into GDP, leading to the accumulation of GTP-KRAS, an active form of KRAS

Novel cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 100 nM and 60.0 nM for h-cGAS and m-cGAS, respectively)

Novel potent inhibitor of Proprotein convertase subtilisin/kexin 9 (PCSK9), targeting the PCSK9/LDLR protein-protein interaction

First-in-Class Chitotriosidase (CHIT1) Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

Novel potent and selective inhibitor of ketohexokinase (KHK)

Novel potent dCTP Pyrophosphatase 1 (DCTPP1) inhibitor

Novel potent dCTP Pyrophosphatase 1 (DCTPP1) inhibitor

Novel potent inhibitor of IRAK1/4 and FLT3 with improved solubility, stability, and permeability properties suitable for in vivo utility

The first selective inhibitor of DAPK1

Idiotype-specific blocker of neuromyelitis opticaimmunoglobulin G (NMO-IgG) binding to aquaporin-4 (AQP4)

Novel serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2

A research chemical with highly selective dopaminergic stimulant and antibiotic properties.