Potent influenza A virus (IAV) entry inhibitor, targeting a conserved region of hemagglutinin

Potent inhibitor of Dengue viruses (DENV), displaying activities against all four serotypes of DENV, as well as to a related flavivirus, West Nile virus (WNV), and an alphavirus, Sindbis virus (SINV)

Novel dual-targeted inhibitor of sphingosine kinase and microtubule polymerization

Selective, brain penetrant 5-HT(1B/D) receptor agonist

Dopamine D1 receptor agonist

Inhibitor of Aβ self-aggregation

Novel inhibitor of HIV-1 infection by blocking viral DNA nuclear entry

Novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity

Novel potent EGFR degrader, being capable of penetrating the cell membrane, also degrading an exon-20 insertion mutant form of EGFR (ASV duplication)

Novel selective EGFR degrader

Novel BRAF-targeting PROTAC, inducing efficient and potent degradation of mutant BRAF but sparing BRAFWT, inhibiting cell growth in mutant-BRAF driven cancer cells

Novel selective MDMX antagonist

Novel Inhibitor of the Disordered Protein, p27(Kip1)

Novel inhibitor of MAGE-A11 with robust activity in TR-FRET for disrupting MAGE-A11:PCF11 interaction (IC50 0.40 μM)

Unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1), also inhibiting HIV-2

Novel inhibitor of MAGE-A11 with robust activity in TR-FRET for disrupting MAGE-A11:PCF11 interactionm being cell permeable and having improved activity in the TR-FRET assay (IC50 0.13 µM)

Novel inhibitor of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 on microglia, exhibiting anti-inflammatory activity through ER-stress-mediated autophagy, significantly inducing the conversion ratio of LC3 II/I and

Fluoroquinolone antibiotic, acting as antibacterial, antineoplastic, anti-Infective agents, Inhibiting DNA-gyrase and topoisomerase

Potent broad spectrm fluoroquinolone antibiotic

Novel in situ tetrazine ligation reactive silicon-rhodamine dye

Novel selective SIRT3 inhibitor, exhibiting SIRT3 inhibitory selectivity with IC50 value of 7.2 µM over SIRT1 (32.6 µM) and SIRT2 (33.5 µM), showing potent inhibitory activity against a group of MLLr leukemic cell lines

Potent and selective inhibitor of SIRT2

Novel SIRT1 inhibitor, inducing apoptosis in HCT116 human colon carcinoma cells partially by activating p53

Novel SIRT1 Inhibitor, showing potent effect on prostate cancer cell line

First-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, normalizing sirtuin 1 levels and improving cognition in an Alzheimer's disease mouse model

Novel SIRT1 Activator

Novel farnesoid X receptor antagonist

Novel D2/5-HT2A Receptor Dual Antagonist

Antioxidant and antimicrobial agent, counteracting mitochondrial oxidative stress in cardiomyocytes

Peroxisome proliferator