Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER), acting as a protein degradation inducer of oncogenic BCR-ABL protein

Highly selective alpha1A-adrenoceptor antagonist

Potent and selective GAL3 antagonist

Novel Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo

Novel specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188)

Novel potent DNA-binding topoisomerase II-directed antitumor agent.

Selective ligand of GC-rich sequences in DNA

Novel Smurf1 inhibitor, promoting bone formation in mouse models of distinctive age-related osteoporosis

Novel dual inhibitor of thrombolysis and soluble epoxide hydrolase

Second-generation modulator of utrophin, increasing utrophin expression in skeletal, respiratory and cardiac muscles

Novel specific splicing enhancer, targeting RNA for a specific splicing correction, recognizing the interface between U1 snRNP and the SMN2 E7 5ʹ SS, promoting the U1-C zinc finger RNA duplex binding activity

Novel Stablizer of Survival of Motor Neuron 2 (SMN2) , Post-Translationally Stablizing SMN Protein for the Treatment of Spinal Muscular Atrophy (SMA)

Novel Active Site Inhibitor of Oncogenic K-Ras G12C

Selective, direct-acting covalent inhibitor of the K-Ras G12C mutant relative to wild-type Ras

Novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor

Novel TLR2 agonist, promoting cross-presentation by mouse and human antigen presenting cells

Novel enhancer of the cyclin-dependent kinase (CDK) inhibitor p27(Kip)

Novel strathclyde minor groove binder (S-MGB), curing animal African trypanosomiasis (AAT)

Novel enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin

Novel Allosteric Inhibitor of p97

Fluorogenic fluorescent probe for imaging lipid droplets; suitable for use with two-photon microscopy

Novel inhibitor of Loxosceles sphingomyelinases D (SMases D)

Novel inhibitor of Loxosceles sphingomyelinases D (SMases D)

Potent inhibitor of microtubule polymerization

Potent inhibitor of microtubule polymerization

Novel activator of PP1, inducing HIV-1 transcription, reactivation of latent HIV-1 in chronically infected cells, and CDK9 phosphorylation

Proapoptotic and anti-inflammatory agent, inducing apoptosis by inhibiting apoptosis proteins (IAPs)

Novel inhibitor of IL-1

Novel potent and selective inhibitor of galactokinase (GALK1)

Non-peptidic Smac mimetic, binding to XIAP, cIAP-1 and cIAP-2 proteins with higher affinities in cell growth inhibition in the MDA-MB-231 cell line