Novel inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity

Cell-permeable superoxide dismutase (SOD) mimetic

Potent and selective Mnk2 inhibitor

Novel highly potent and selective MNK1/2 kinases inhibitor

Novel anticancer agent, inducing apoptosis, inhibiting migration and invasion

First-in-class acetyl-CoA synthetase (AcAS) inhibitor, showong single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocking P. falciparum transmission to Anopheles mosquitoes

Novel potent broad antiparasitic agent against intracellular Leishmania amastigotes, Trypanosoma brucei, and Plasmodium falciparum

Novel potent inhibitor of P. falciparum asexual blood stages, inhibiting heme detoxification

Selective allosteric inhibitor of Plasmodium Kinesin-5

Novel antimalarial agent, targeting P. falciparum farnesyltransferase PfFT, showing remarkable growth inhibition with EC50 value of 0.4 µM and presenting good selectivity index (SI > 250)

Novel antimalarial agent against Plasmodium falciparum

Novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites

Novel antimalarial agent with increased efficacy against one or more pfatp4 mutated clones

Novel antischistosomal agent against chronic S. mansoni infection

Novel antischistosomal agent against chronic S. mansoni infection

Novel Inhibitor of Plasmodium falciparum

Novel antimalarial agent with increased efficacy against one or more pfatp4 mutated clones

Novel MEP pathway-targeting antimalarial agent

Novel potent Plasmodium lactate transporter PfFNT

Novel antimalarial agent against asexual stages of P. falciparum

The first small-molecule anti-plasmodial agent, disrupting rosetting, simultaneously restoring microcirculation and reduce parasite load

Novel inhibitor of lanosterol-14-alpha-demethylase (TcCyp51)

Highly water-soluble antifibrotic agent, reducing the profibrotic phenotype induced in vitro in primary human fibroblasts and ameliorating bleomycin-induced pulmonary fibrosis in vivo

Novel Mmpl3 inhibitor, indirectly blocking translocation of Trehalose Monomycolates across the IM

Negative allosteric modulator (NAM) ligand for the mGlu5 receptor

Novel highly potent and selective MMP13 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme