Novel potent and selective MALT-1 protease inhibitor, showing improved solubility and permeability in comparison with MLT-748

Potent agonist of TRPML channels specifically activating lysosomal ML1 currents

Novel inhibitor of human cytomegalovirus (HCMV) infection

Novel dual JAK/Src kinase inhibitor, suppressing growth of diverse cancer cells

Potent inhibitor of STAT3 and Akt signaling

Novel Inhibitor of Human Cytomegalovirus

Novel potent inhibitor of EBOV infection

Potent and selective mixed-type inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2)

Potent and selective competitive inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2)

Novel selective and potent inhibitor of recombinant h12/15-LOX and cellular mouse 12/15-LOX (m12/15-LOX)

Second generation 5-LO inhibitor, blocking the production of leukotrienes

Novel potent DNA binding agent, stabilizing topoisomerase-dependent cleavage, demonstrating exceptional efficacy against a number of murine and human tumor models

Novel IKK2 inhibitor, decreasing NF-κB activation and down-regulating the expression of a number of inflammatory proteins

Selective inhibitor of Myosin Light Chain Kinase (MLCK)

Novel Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake

Novel endoplasmic reticulum proteostasis modulator, enhancing insulin production in pancreatic β cells, inhibiting the UPR, alleviating ER stress and protein aggregation, improving intracellular insulin levels and insulin secretion

Novel highly specific, potent, orally bioavailable MKP5 inhibitor

Novel potent and selective MKK3/6 inhibitor

Prodrug of raltegravir with enhanced colonic absorption

Novel agonist of G-protein coupled receptor 40 (GPR40)

Novel liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)

Novel bombesin receptor subtype-3 (BRS-3) modulator

Novel potent muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator (PAM)

Novel nonpeptide bombesin receptor subtype-3 agonist

Novel Selective Androgen Receptor Modulator (SARM)

Potent and selective human type-1 5alpha-reductase inhibitor

Potent TRPV1 antagonist

Novel renin inhibitor

Novel Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

Selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor