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SSCI-2

  Cat. No.:  DC70805   Featured
Chemical Structure
2441748-86-1
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More than 5000 active chemicals with high quality for research!
Field of application
SSCI-2 is a highly potent, selective NaV1.7 inhibitor with IC50 of 9 and 17 nM on human and rhesus Nav1.7 channels, respectively.SSCI-2 showed robust selectivity over other human and rhesus Nav channel paralogs, with the exception of Nav1.2 channels (IC50 183 nM for hNaV1.2), shows no other channels and receptors in 114 enzymatic, radioligand binding, and cellular assays.SSCI-2 also exhibits high potency in manual patch clamp experiments (IC50=24/62 nM for huma/rhesus Nav1.7 channels).SSCI-2 inhibits withdrawal responses to noxious heat in rhesus monkeys.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2441748-86-1
Chemical Name: SSCI-2
Synonyms: SSCI-2;4-[[(2S,3R)-3-Amino-2-[[1-(2-aminoethyl)cyclobutyl]methyl]butyl]amino]-2,5-difluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide
SMILES: C(C1(CCC1)CCN)[C@]([H])([C@H](N)C)CNC1C=C(F)C(S(=O)(=O)NC2SN=CN=2)=CC=1F
Formula: C19H28F2N6O2S2
M.Wt: 474.59142780304
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC73683 LTGO-33 LTGO-33 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.8 with IC50 of 44 nM (hNaV1.8), 600-fold selectivity against NaV1.1-NaV1.7 and NaV1.9.
DC70805 SSCI-2 SSCI-2 is a highly potent, selective NaV1.7 inhibitor with IC50 of 9 and 17 nM on human and rhesus Nav1.7 channels, respectively.SSCI-2 showed robust selectivity over other human and rhesus Nav channel paralogs, with the exception of Nav1.2 channels (IC50 183 nM for hNaV1.2), shows no other channels and receptors in 114 enzymatic, radioligand binding, and cellular assays.SSCI-2 also exhibits high potency in manual patch clamp experiments (IC50=24/62 nM for huma/rhesus Nav1.7 channels).SSCI-2 inhibits withdrawal responses to noxious heat in rhesus monkeys.
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DC47939 NBI-921352 NBI921352 is a Nav1.6 inhibitor with an IC50 value of 3.765 μM.
DC28765 Ethacizine hydrochloride Ethacizine hydrochloride (Ethacizin; NIK-244) is a Class Ic antiarrhythmic agent, which means it is part of a group of drugs that primarily act by blocking sodium channels in the heart. This class of antiarrhythmic agents is known for their potent effects on slowing conduction in the heart, particularly in the atria, ventricles, and the His-Purkinje system.
DC28483 Nav1.1 activator 1 Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6.
DC7287 Ralfinamide Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.
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