Novel orally active IKK2 inhibitor

Novel IKK-β inhibitor, reducing the secretion of TNF-α, IL-1β, IL-6, IL-12, IFN-γ and increased secretion of IL-10, protecting gastrointestinal homeostasis

Novel Adenosine A2a Receptor Agonist, Attenuating the Progression of Monocrotaline-induced Pulmonary Hypertension

Novel adenosine receptor agonist, inducing relaxation of corpus cavernosum; Novel selective phosphodiesterase-​4 (PDE4) inhibitor associated with anti-​TNF-​α properties

Novel dual TRPV1 antagonist and TNF-alpha production inhibitor

Lipopeptide antibiotic with activity against a range of Gram-positive bacteria including drug-resistant pathogens

Natural fungal phytotoxin, activating the plant jasmonic acid pathway

Novel, potent and selective CRTh2 antagonist

Potent inhibitor of histone deacetylase

Novel Modulator of autoimmune demyelination

Novel Peptide Deformylase Inhibitor against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus

Glutamate receptor antagonist and radical scavenging agent

Top1mt inhibitor, targeting mitochondrial DNA

Adenosine A1 receptor antagonist, reducing allergic responses to house dust mite in an allergic rabbit model of asthma, improving survival and protecting the kidney in a rat model of cecal ligation and puncture induced sepsis, also improving survival and

The first organ-selective thyromimetic, lowering plasma low density lipoprotein (LDL) cholesterol and raising plasma high density lipoprotein (HDL) cholesterol levels

Novel inhibitor of HIV-1 and SIV integrase

Chemically-modified forskolin with greater stability and water solubility than the parent compound

Novel HIV-1 integrase strand transfer inhibitor (INSTI), stabilizing an integrase-single blunt-ended DNA complex

Potent and selective agonist of the human beta3 adrenergic receptor

Class III antiarrhythmic agent, selectively blocking the slowly activating cardiac delayed rectifier potassium current Iks

Dual ET(A)/ET(B) endothelin receptor antagonist

Ras farnesyltransferase inhibitor, inhibiting in p70(s6k) phosphorylation in mammary tumors, inducing tumor regression in transgenic mice by mediating alterations in both cell cycle control and apoptosis

Potent glycoprotein IIb/IIIa inhibitor

Inhibitor of the KCNQ1 channel

Inhibitor of Strand Transfer, Preventing Integration and Inhibiting HIV-1 Replication in Cells

Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1)

HIV-1 non-nucleoside reverse transcriptase inhibitor

Novel partial agonist of muscarinic M1 receptors

HIV protease inhibitor

Potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNL-E)