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BSJ-03-204

  Cat. No.:  DC36898   Featured
Chemical Structure
2349356-09-6
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More than 5000 active chemicals with high quality for research!
Field of application
BSJ-03-204 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-03-204 is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2349356-09-6
Chemical Name: BSJ-03-204
Synonyms: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide;GTPL10530;BSJ-03-204
SMILES: O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=CC=C(C=N3)N3CCN(CCCCNC(COC4=CC=CC5C(N(C(C=54)=O)C4C(NC(CC4)=O)=O)=O)=O)CC3)N=C2N1C1CCCC1
Formula: C43H48N10O8
M.Wt: 832.903429031372
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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COA
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