CSLP37 |CAS 2244984-64-1|DC Chemicals

Cas No.:	2244984-64-1
Chemical Name:	NC1=NC=C(C=C1C=1C=C(C(=C(C=1)NS(=O)(=O)Ccc)OC)F)C1=CC=C(C=C1)N1ccncc1
Synonyms:	CLSP37;NSC801412;NC1=NC=C(C=C1C=1C=C(C(=C(C=1)NS(=O)(=O)CCC)OC)F)C1=CC=C(C=C1)N1CCNCC1;N-(5-(2-Amino-5-(4-(piperazin-1-yl)phenyl)pyridin-3-yl)-3-fluoro-2-methoxyphenyl)propane-1-sulfonamide
SMILES:	S(CCC)(NC1C(=C(C=C(C=1)C1=C(N)N=CC(=C1)C1C=CC(=CC=1)N1CCNCC1)F)OC)(=O)=O
Formula:	C₂₅H₃₀FN₅O₃S
M.Wt:	499.600807666779
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CSLP37 (RIPK2 inhibitor CSLP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling; exhibits inhibition of TNF release from RAW264.7 cells with EC50 of 12.6 nM, inhibits NF-κB reporter activity with IC50 of 22.5 nM; antagonizes NOD2 signaling by interfering with the XIAP-RIPK2 interaction, selectively inhibits NOD responses in cells (HEKBlue NOD2 IC50=26.3 nM) and displays potent activity in vivo, does not attenuates the TNF release following an unrelated pro-inflammatory stimulation mediated through TLR4 activation by LPS at 1 uM.

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