Morin derivative, enhancing neural glyoxalase pathway (GP) activity and preventing methylglyoxal-mediated oxidative stress (OS) in an AD model

Histamine H1-receptor antagonist

Novel Inhibitor of the AAA-ATPase Drg1, blocking ribosome biogenesis

Selective alpha4beta2 nAChR partial agonist for the treatment of nicotine dependence to assist in smoking cessation

Novel probe for protein S-sulfinylation from cells

Novel potent and selective STING agonist, activating secretion of IFNβ, IL-6, TNF, and KC/GROα, exhibiting durable anti-tumour effects

Novel STING agonist with enhanced binding to STING and cellular function, displaying strong anti-tumour activity

Novel potent, selective and covalent inhibitor of DCN1, selectively inhibiting neddylation of cullin 3 in cells

The most potent inhibitor of sodium iodide symporter (NIS) reported to date

Novel Pim kinase inhibitor

Novel inducer of autophagic cell death through upregulation of HMGB1 in A549 cells

Novel growth inhibitor of both triple-positive and triple-negative human breast cancer cell lines

Novel HCV NS3 degrader, reducing susceptibility to resistance mutations, potently inhibiting HCV in a cellular infection model, exhibiting the most potent degradation (DC50 of 50nM at 4h) of HCV NS3,

Abundant lipid in the membranes of many algae, lower plants, and fungi, showing an inverse concentration relationship with phosphatidylcholine, being capable of replacing phosphatidylcholine

Novel human α-galactosidase A ligand, capable of stabilizing α-Gal A and restoring trafficking

The major adduct formed by the food-borne carcinogen, PhIP with DNA

Selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2)

Novel potent, orally active inhibitor of LTA4H

Proteolysis targeting chimeras (PROTAC), potently decreasing FKBP12 abundance in MV4;11 cells, leading to over 80% reduction of FKBP12 at 0.1 μM and 50% reduction at 0.01 μM

Cell-permeable, reversible and selective inhibitor of ɣ-secretase

Potent Squalene Synthase Inhibitor

5-HT3 Receptor antagonist; Antitussive; Anti-inflammatory; Antiasthmatic

Natural modulator of mu-, delta-, and kappa-opioid receptors

Norepinephrine-dopamine reuptake inhibitor (NDRI)

Cholecystokinin antagonist, selective for the CCKA subtype

Glucocorticoid, Anti-inflammatory Agent

Pro-drug of dexamethasone, anti-inflammatory glucocorticoid, stimulating glutamine uptake in the cerebral cortex

Cysteine reactive protein labeling agent

PET precursor of preparing radiolabel [11C]HD-800, a high affinity brain penetrant PET tracer for imaging microtubules

Primary metabolite of diazepam, binding to the GABA A receptor benzodiazepine modulatory site