VY-3-135 is an orally active, selective acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 value of 44 nM. VY-3-135 displayes no inhibitory activity towards recombinant human ACSS1 or ACSS3. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. VY-3-135 inhibits triple negative breast cancer (TNBC) tumor growth in mouse ACSS2high but not ACSS2low tumors models.

DMG-PEG2000-NHS is a PEG derivative that can be used in various biomedical applications, such as the construction of drug delivery systems (siRNA delivery liposomes, lipid nanoparticle, etc.). The active ester (NHS) can react with an amino group (-NH2) to form a stable amide bond, which can be used as a linker in a bioconjugation strategy to modify amino-linked peptide proteins as well as other small molecules.

Phospholipids DSPE belong to the lipid family of biopolymers. Phospholipids consist of two fatty acids, a glycerol unit, a phosphate group, and a polar molecule. The phosphate groups and polar head regions of the molecule are hydrophilic (attracted to water), while the fatty acid tail is hydrophobic (repelled by water). When placed in water, the phospholipids Orient themselves into a double layer, where the non-polar tail region faces the inner region of the double layer. The polar head region faces outward and interacts with the water. Applications in drug release, nanotechnology and new materials research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and pegylated modified functional coatings and other active compounds.

Modified phospholipid products: it is to modify the amino group (primary amino group) -NH3 at the end of DSPE into NHS, COOH, N3, MAL, Thiol (SH), OPSS, FITC, FA, Biotin and other different active groups. Phospholipids DSPE belong to the lipid family of biopolymers. Phospholipids consist of two fatty acids, a glycerol unit, a phosphate group, and a polar molecule. The phosphate groups and polar head regions of the molecule are hydrophilic (attracted to water), while the fatty acid tail is hydrophobic (repelled by water). When placed in water, the phospholipids Orient themselves into a double layer, where the non-polar tail region faces the inner region of the double layer. The polar head region faces outward and interacts with the water.

Phosphatidyl amino DSPE-NH2 is one of the most common materials in polymer modification. By grafting phospholipid bonds to amino molecules, polymeric polymers with different chain segments are formed by using phospholipid molecules, which reduces the thermal stability and weather resistance of the materials. At the same time, by introducing modifiers to improve the water resistance of the polymer itself, improve its processing performance, and finally obtain good water resistance, high mechanical properties, good weather resistance, good acid and alkali resistance products. DSPE-NH2 material is mainly composed of isopropyl alcohol butadiene, the isopropyl alcohol butadiene mixture is an aromatic polymer, with strong water absorption, hydrophilicity, and wide molecular weight distribution, good solubility, high mechanical strength characteristics, so the material can be used in many fields.

Phospholipids DSPE belong to the lipid family of biopolymers. Phospholipids consist of two fatty acids, a glycerol unit, a phosphate group, and a polar molecule. The phosphate groups and polar head regions of the molecule are hydrophilic (attracted to water), while the fatty acid tail is hydrophobic (repelled by water). When placed in water, the phospholipids Orient themselves into a double layer, where the non-polar tail region faces the inner region of the double layer. The polar head region faces outward and interacts with the water. Applications in drug release, nanotechnology and new materials research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and pegylated modified functional coatings and other active compounds.

Phospholipids DSPE belong to the lipid family of biopolymers. Phospholipids consist of two fatty acids, a glycerol unit, a phosphate group, and a polar molecule. The phosphate groups and polar head regions of the molecule are hydrophilic (attracted to water), while the fatty acid tail is hydrophobic (repelled by water). When placed in water, the phospholipids Orient themselves into a double layer, where the non-polar tail region faces the inner region of the double layer. The polar head region faces outward and interacts with the water. Applications in drug release, nanotechnology and new materials research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and pegylated modified functional coatings and other active compounds.

Phospholipids DSPE belong to the lipid family of biopolymers. Phospholipids consist of two fatty acids, a glycerol unit, a phosphate group, and a polar molecule. The phosphate groups and polar head regions of the molecule are hydrophilic (attracted to water), while the fatty acid tail is hydrophobic (repelled by water). When placed in water, the phospholipids Orient themselves into a double layer, where the non-polar tail region faces the inner region of the double layer. The polar head region faces outward and interacts with the water. Applications in drug release, nanotechnology and new materials research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and pegylated modified functional coatings and other active compounds.

2-Distearoyl-sn-Glycero-3-Phosphoethanolamine(DSPE) conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol, which has hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposomes can be used for drug delivery, gene transfection and vaccine delivery. Pegylated phospholipids can significantly improve blood circulation time and stabilize drug encapsulation. These materials can also be used for targeted drug delivery by modifying ligands with target surfaces such as antibodies and peptides,Liposomes.

DSPE-PEG-AC phospholipid PEG derivative used in the preparation of liposomes, phospholipatized polyethylene glycol binding has both hydrophilic and hydrophobic properties. Acrylate functionalized PEG is a common polymer for preparing biocompatible and biodegradable hydrogels and other biopolymers. Functionalized polyethylene glycol can be used to modify proteins, peptides, and materials, but also to increase solubility and stability, and reduce peptide and protein immunogenicity. It can also inhibit the non-specific combination of charged molecules to modify the surface. The product can be used in drug release, nanotechnology and new materials research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and pegylated modified functional coatings and other active compounds.

DSPE phospholipids can be used as pharmaceutical excipients for emulsification and drug solubilization, and are important materials for slow release drug preparations such as liposomes, fat milk and nanoparticles in recent years. Modification of phospholipid molecules can make these preparations have the ability of release and targeting under specific conditions. Common modification methods include: disintegration time; Introducing immune factors to enhance targeting; Introduce markers for diagnosis and tracking. A covalent bond in the carbonyl group is connected to the hydrogen atom and formed by a univalent atomic group, called aldehyde group, aldehyde group structure simple formula is -CHO, aldehyde group is a hydrophilic group, so the organic matter with aldehyde group (such as acetaldehyde, etc.) has a certain water solubility. Aldehydes, sugars, aldehydes, glucose, maltose and other molecules contain aldehyde groups. The aldehydes are active and prone to condensation and nucleophilic addition reactions. The aldehyde group can be reduced to hydroxymethyl (-CH2OH) or oxidized to carboxylic (-COOH).

RGD's receptors are integrins αvβ3 and αvβ5, which can mimic cell adhesion proteins and bind specifically to 11 kinds of integrins, which can effectively adhere to biological materials. DSPE-PEG-RGD can be used to make micelles and vesicles. The liposomes formed by RGD-PEG-DSPE can act directly on the target to form an active targeting effect. Rgd-peg-dspe peptide RGD polyethylene glycol phospholipid can be used for passive targeting of micelles and vesicles, active targeting research and drug delivery. DSPE (1, 2-distearoyl-SN-glycerol-3-phosphate ethanolamine) is a saturated 18-carbon phospholipid commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) -coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection, and biomolecular modification. Polyethylene glycol can enhance solubility and stability, reduce the nonspecific binding of charged molecules, and reduce the immunogenicity of polypeptides.

DSPE phospholipids can be used as pharmaceutical excipients for emulsification and drug solubilization, and are important materials for slow release drug preparations such as liposomes, fat milk and nanoparticles in recent years. Modification of phospholipid molecules can make these preparations have the ability of release and targeting under specific conditions. Common modification methods include: disintegration time; Introducing immune factors to enhance targeting; Introduce markers for diagnosis and tracking.

SM-6.1 is a small molecule delivery vehicle developed by Arrowhead, targeting αvβ6, which selectively delivers therapeutic siRNA to lung epithelial cells and mediates durable gene silencing post-inhalation.

Polyethylene glycol phospholipid is an excellent material to form liposomes, which can be used for gene transfection, vaccine delivery, drug transportation, and targeted drug delivery. Phospholipids are hydrophobic and hydrophilic. It can be used to modify protein drugs, peptide compounds, organic small molecule drugs, biological materials, etc. Cy7 labeled PEG derivatives are used for fluorescence tracing or fluorescence observation.

DSPE-PEG-NPC is a linear heterobifunctional polyglycolation reagent containing DSPE phospholipids and NPC groups. It is a useful self-assembly reagent for preparing PEGylated liposomes or micelles, and also provides a combination of NPC group and thiol containing molecules.

DSPE-PEG-FITC, is a fluorescein attached PEG lipid. It can be used to prepare liposomes as drug carrier in targeted drug delivery. The polymer is modified with fluorescein (green) dye which can be used for staining cells, tissues, biomarkers, or nanoparticles.

DSPE-PEG-OPSS, DSPE (1,2-distearoyl-sn-glycerol-3-phosphoethanolamine) is a saturated 18 carbon phospholipid, commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) - coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection and biomolecular modification. The PEG of phospholipid significantly improved the blood circulation time and stability of the capsule drug. Polyethylene glycol can enhance the solubility and stability, reduce the non-specific binding of charged molecules on the surface, and reduce the immunogenicity of polypeptides. Mercaptopyridine reacts with mercapto group to release pyridine ring and generate stable disulfide bond.

Macrocyclic ligands are ring complexes formed by multi-dentate ligands with O, N, P, S and other coordination atoms on the ring skeleton. The range of complexes is wide. According to their structural characteristics, complexes can be divided into the following types: simple complexes, chelates, polynuclear complexes, carbonyl complexes, metal clusters, sandwich complexes, and macrocyclic ligand complexes.