SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models.

AKT-100 is a p53 reactivation agent. AKT-100 significantly inhibits the proliferation of various ovarian and endometrial cancer cells at low concentrations. AKT-100 can upregulate cell cycle regulatory genes (such as p21, GADD45) and pro apoptotic genes (such as NOXA, DR5), and inhibit DNA repair pathways. AKT-100 is commonly used in cancer research.

(Rac)-VB-201 is the racemate of VB-201, an oxidized phospholipid small molecule that inhibits CD14- and toll-like receptor 2-dependent innate cell activation and suppresses atherosclerosis.

Cytaphat is a compound with hepatoprotective activity. Cytaphat has antioxidant, membrane-stabilizing and choleretic effects. Cytaphat can be used in the research of diseases such as acute toxic hepatopathy and liver injury.

Rp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y2 receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y2-expressing 1321N1 cells with an EC50 of 12.5 μM.

NLCQ-1 (NSC 709257) is an orally active antibacterial agent targeting dormant Mycobacterium tuberculosis. NLCQ-1 is promising for research of tuberculosis.

IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection.

HC2210 has an antibacterial effect against Mycobacterium abscessus (Mab) (EC50: 0.72 µM). HC2210 modulates the expression of Mab genes related to oxidative stress and lipid metabolism. HC2210 can be used in the study of Mab infection.

TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg)[1][2].

E3 ligase Ligand 76 is a E3 ligase ligand that can be used in the recruitment of VHL protein. E3 ligase Ligand 76 can be connected to the KRAS ligand by a linker to synthesis of PROTAC KRAS(on) degrader ACBI-4.

Leucodelphinidin (Leukoefdin) is a flavonoid found in Terminalia plants with antiplasmodial activity against Plasmodium falciparum (3D7 and Dd2 strains). Leucodelphinidin exhibits cytotoxicity (CC50>250 μg/mL) toward Vero and Raw 264.7 cells. Leucodelphinidin is promising for research of antimalarial agents.

Ro-65-2299 is an orally active retiferol Vitamin D analogue and a potential VDR agonist (ED50 = 180 nM). Ro-65-2299 can induce thickening of the epidermis and exhibits antipsoriatic effect in hairless mice (ED50 = 7.5 mg/kg). Ro-65-2299 can be used for the researches of inflammation and immunology, such as psoriasis.

Rp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) (Rp-dADP-α-S) sodium is an isomer of Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium.

Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) (Sp-dADP-α-S) sodium is an isomer of Rp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium.

Cyanine 3-dCTP is a Cy3-labeled nucleotide and can be used for DNA synthesis.

Rp-TTPαS (tetrasodium) is the Rp-isomer of TTPαS (tetrasodium). Rp-TTPαS (tetrasodium) incorporate with HIV-1 reverse transcriptase (HIV-1 RT) with HIV-1 RT with large phosphorothioate elemental effects.

Sp-TTPαS tetrasodium is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS tetrasodium competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM.

8-Oxo-dGTP is an oxidized guanine nucleotides and acts as a crucial biomarker for oxidative stress.

5-Iodo-dCTP is a good substrates for DNA polymerases and can be used for DNA synthesis.

D-myo-Inositol-1,2,6-triphosphate (sodium) is one of the members in inositol phosphate family of second messengers that play an important role in transmitting cellular signals. D-myo-Inositol-1,2,6-triphosphate (sodium) can open calcium channels and increase intracellular calcium upon binding to its receptor on the endoplasmic reticulum.

MRS-4203 is an ADK (IC50 = 88 nM) inhibitor. MRS-4203 can reduce DNA methylation. MRS-4203 is commonly used in cancer research.

Adenosine-5'-O-diphosphoribose phosphate sodium is a structural analog of NADPH). Adenosine-5'-O-diphosphoribose phosphate sodium is an HMG-CoA reductase inhibitor. Adenosine-5'-O-diphosphoribose phosphate sodium inhibits microsomal HMG-CoA reductase with an apparent Ki value of 550 μM at low thiol concentrations.

20:4 Lyso PI is a selective G protein-coupled receptor GPR55 agonist. 20:4 Lyso PI triggers cell rounding in GPR55-expressing HEK293 cells, with an EC50 value of 10 nM. 20:4 Lyso PI promotes RhoA activation and subsequent ROCK-dependent cytoskeletal rearrangement. 20:4 Lyso PI activates the ERK signaling pathway and elevates intracellular free calcium. 20:4 Lyso PI can be used for the study of immune diseases.

Isovaleryl-CoA sodium, a branched-chain acyl CoA, is a succinate:CoA ligase (SCL) inhibitor with an IC50 of 273 μM in rat liver mitochondria.

6-Bn-ADP (N6-benzyl ADP) sodium is a derivative of Adenosine 5'-diphosphate (ADP) that inhibits ATP hydrolysis. 6-Bn-ADP sodium inhibits the ATPase activities of Mortalin, Hsc70, and Hsp70 protein with Kis of 86.51 μM, 294.5 μM, and 1612 μM, respectively.

GDP-Fuc-AM-VcPAB-MMAE is a conjugate of toxic molecules and linkers. GDP-Fuc-AM-VcPAB-MMAE is an important precursor molecule that can be used to prepare ADC drugs. GDP-Fuc-AM-VcPAB-MMAE can be used for cancer research.

GMPCP (GpCp) trisodium (Compound 7 trisodium) is a guanosine derivative is a CD73 inhibitor, with Kis of 1110 nM (rat soluble CD73) and 410 nM (human soluble CD73) respectively. GMPCP (GpCp) trisodium can be used for research of cancer.

CI-936 (MRS-3310) is an orally active A2 agonist with 25 nM affinity. CI-936 produces potent and selective effects in preclinical tests predictive of antipsychotic efficacy. CI-936 inhibits exploratory activity in mice.

Uridine 5'-O-thiodiphosphate (trisodium) (UDP-β-S (trisodium)) is a purinergic P2Y6 receptor agonist. Uridine 5'-O-thiodiphosphate (trisodium) selectively induces accumulation of inositol phosphates in 1321N1 cells expressing P2Y6 receptors (EC50 = 28 nM). Uridine 5'-O-thiodiphosphate (trisodium) induces DNA synthesis in rat aortic smooth muscle cells.

Rp-UTP-α-S (tetrasodium) is a nucleotide agonist of purinergic P2Y2 and P2Y4 receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y2 or P2Y4 expressing 1321N1 cells with EC50 values of 5.4 and 27 μM.