AhR modulator-1 |CAS 118174-38-2|DC Chemicals

Cas No.:	118174-38-2
Chemical Name:	Dibenzofuran,1,3,8-trichloro-6-methyl-
Synonyms:	Dibenzofuran,1,3,8-trichloro-6-methyl-
SMILES:	ClC1=CC(Cl)=C2C3C=C(Cl)C=C(C)C=3OC2=C1
Formula:	C₁₃H₇Cl₃O
M.Wt:	285.55308
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC73809	ITE	A endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro.
DC28934	VAF347	VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.
DC28914	AhR modulator-1	AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus.
DC11794	GNF-351	GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential; antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibit both DRE-dependent and -independent activity; decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.
DC11530	Tapinarof (Benvitimod; GSK2894512)	Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.