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WNK463

Cat. No.: DC9883 Featured

Chemical Structure

2012607-27-9

For research use only. We do not sell to patients.

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Field of application

WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	2012607-27-9
Chemical Name:	WNK 463，WNK-463
Synonyms:	WNK 463，WNK-463
SMILES:	CC(C)(C)NC(=O)C1=CN=CN1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F
Formula:	C₂₁H₂₄F₃N₇O₂
M.Wt:	463.46

Description:

WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively.

Cat. No.	Product name	Field of application
DC12501	WNK-IN-11	WNK-IN-11 is a potent, selectiive and orally active inhibitor of WNK1 kinase.
DC9883	WNK463	WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.