TAK 653 (also known as NBI 1065845) is an oral small molecule, positive allosteric modulators of AMPA (AMPA-PAM) receptors

Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.

Cyclam (1,4,8,11-tetraazacyclotetradecane) is an organic compound. It is a white solid that is soluble in water. The compound is notable as a macrocyclic ligand, which binds strongly to many transition metal cations. The compound was first prepared by the reaction of 1,3-dibromopropane and ethylenediamine.

Artemisitene is an antimalarial agent and the oxidized form of Artemisinin. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinic acid, Artemisinin B, Artemisitene, etc.

Pimozide is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5.

CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.

ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.

A novel Glucocorticoid receptor modulator.

TG-89 is a JAK inhibitor. It has IC50 values of 6, 25, 17 and 169 nM against JAK2, FLT3, RET and JAK3 respectively.

Ginkgolic acid C17:1 (GAC 17:1) 通过废除上游的 JAK2 和 Src 来抑制 STAT3 的组成性激活。Ginkgolic acid C17:1 可以诱导 PTEN 和 SHP-1 的大量表达。Ginkgolic acid C17:1 诱导肿瘤细胞凋亡。

Novel lipid-lowering agent, acting as an AMPK activator, increasing ABCA1 protein expression and improving hepatic lipid metabolism and leukocyte trafficking in experimental hepatic steatosis

CAY10781 is an inhibitor of the protein-protein interaction between NRP-1 and VEGF-A

Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib can be used for the research of multiple sclerosis (MS).

TKN87180 is a Hydrolyzable linker for making ADC conjugate. TKN87180 was first reported in Bioorganic & Medicinal Chemistry Letters (2004), 14(16), 4323-4327. This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digits of its CAS number or its molecule weight if its CAS number is not available.

WWL-154 is a serine hydrolase inhibitor. Serine hydrolases (SHs) are-​one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders.

Novel proteasome inhibitor, inducing human myeloid tumor-selective apoptosis

L-LEUCINE-13C6, also known as 13C6-D-Leucine or L-​Leucine-​1,​2,​3,​4,​5,​5'-​13C6, is a fully 13C labelled D-Leucine

EMAC10101d is a potent and selective toward hCA II inhibitor, with a Ki of 8.1 nM.

Violanthrone-79 is an n-channel organic semiconductor.

GUN94110 is a WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases. GUN94110 was reported in WO 2019028008. This product has no formal name at the moment.

OUN67600, is a Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonist as Regulators of Chondrogenic Differentiation. OUN67600 was first reported by Atobe et al (compound 36 in J Med Chem. 2019 Feb 14;62(3):1468-1483). OUN67600 has CAS#2314467-60-0, no formal name. For the convenience of scientific communication, we named it as OUN67600 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature.

YUM08164 is a bioactive chemical. YUM08164 has CAS#1333608-16-4, no formal name. For the convenience of scientific communication, we named it as YUM08164 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature.

Prothixene is a biochemical.

Benclonidine is an Antihypertonic agent.

3'-O-Methylguanosine, also known as 3-OMG, is a methylated nucleoside analog and a RNA chain terminator. Early virus-​specific RNA synthesis was preferentially inhibited by 3'-​O-​methyl guanosine.

(Rac)-X77 is a racemate of X77. X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 Mpro). X77 binds to SARS-CoV-2 Mpro with a Kd value of 0.057 μM.

5-Hydroxymethyldeoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).

Gly-AMC, also known as L-Gly-7-Amino-4-Methylcoumarin, is a probe and chromphore substrate for aminopeptidase. it is useful to make the C-​terminal conjugate of ubiquitin with 7-​amino-​4-​methylcoumarin (Ub-​AMC), which is an important probe for fluorescence-​based anal. of deubiquitinating enzyme (DUB) activity.

DUN73423 is a RET/KDR-Selective Inhibitor of RETV804M Kinase with IC50 = 7 nM. DUN73423 was listed in ACS Med Chem Lett . 2020 Feb 28;11(4):497-505 (compound 5). DUN73423 has CAS#2414373-42-3, no formal name For the convenience of scientific communication, we named it as DUN73423 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature .

BMS-986242 is a novel Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1 (IDO1).